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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Age effect on far field potentials from the brain stem after transcutaneous vagus nerve stimulation.
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Age effect on far field potentials from the brain stem after transcutaneous vagus nerve stimulation.

机译：经皮迷走神经刺激后，年龄对脑干远场电位的影响。

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摘要

Recently, a new electrophysiological method for the assessment of vagus nerve function in the brainstem has been proposed in healthy participants. Before this procedure may be applied to patients with neurodegenerative diseases, its feasibility in elderly healthy participants and a possible age effect on the measurement have to be investigated. The vagus sensory evoked potentials (VSEP) after transcutaneous electric stimulation of the sensory auricular branch of the vagus nerve have been assessed in healthy younger and elderly participants. VSEP measured as far field potentials probably originating in vagus nuclei in the brainstem were recorded in 20 of 22 younger as well as in 39 of 43 elderly healthy participants. Latencies were significantly longer in the elderly as compared to the younger participants, while no clear age effects on amplitudes were identified. These results indicate that the assessment of VSEP is feasible also in elderly healthy participants. This is a prerequisite for testing this method in elderly patients with neurodegenerative diseases like Alzheimer and Parkinson disease as a noninvasive tool to detect an affection of the brainstem nuclei of the vagus nerve early in their course.
机译：最近，健康参与者已经提出了一种新的电生理方法来评估脑干中的迷走神经功能。在将该程序应用于神经退行性疾病的患者之前，必须研究其在老年健康参与者中的可行性以及年龄对测量的影响。经皮电刺激迷走神经的感觉性耳廓分支后，迷走神经感觉诱发电位（VSEP）已在健康的年轻和老年参与者中进行了评估。在22岁的年轻人中，有20位以及43位老年健康参与者中的39位中记录了VSEP，其测量的远场电位可能源自脑干的迷走神经核。与年轻参与者相比，老年人的潜伏期明显更长，而没有发现明显的年龄对振幅的影响。这些结果表明，在老年健康参与者中，VSEP的评估也是可行的。这是在患有老年性神经退行性疾病（如阿尔茨海默氏病和帕金森病）的老年患者中测试该方法的先决条件，它是一种无创性工具，可在病程早期检测迷走神经脑干核的影响。

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