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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Effects of flash mode and intensity on P2 component latency and amplitude.
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Effects of flash mode and intensity on P2 component latency and amplitude.

机译：闪光模式和强度对P2分量等待时间和幅度的影响。

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摘要

Alzheimer's disease (AD) groups manifest flash visual-evoked potential (VEP) P2 component delays compared to healthy control groups. However, using P2 latency to categorize individual patients and controls yields low accuracy. Additionally, several laboratories have failed to replicate the basic between group P2 latency findings. The sporadic failure to find the P2 delay and, when found, its failure to classify patients and controls accurately may reflect the use of non-optimal stimuli or recording sites. OBJECTIVE: This was a parametric investigation of stimulation and recording methods in healthy college students. METHOD: Using an extended recording montage of 64 electrodes, 10 stimulus conditions (5 flash intensities through open and closed eyes) were evaluated for their P2 effects. RESULT: The optimal recording site (O2) yielded the most reliable latencies and amplitudes across a range of stimulus intensities. Flash intensity did not affect P2 latency or amplitude. Flashes delivered through closed eyelids produced a flash VEP but delivery through open eyes produced a pattern VEP lacking a flash P2 component. CONCLUSION: This accounts for the failure of some laboratories using open eyes to replicate the P2 delay in AD groups. SIGNIFICANCE: Optimal flash VEP conditions include closed eyes and recording from O2. Flash intensity is unimportant.
机译：与健康对照组相比，阿尔茨海默氏病（AD）组表现出闪光的视觉诱发电位（VEP）P2组分延迟。但是，使用P2潜伏期对各个患者和对照进行分类会导致准确性下降。此外，一些实验室未能在P2组潜伏期发现之间重复基本实验。偶然发现P2延迟失败，一旦发现，则无法准确分类患者和对照，可能反映了使用非最佳刺激或记录位点。目的：这是对健康大学生的刺激和记录方法的参数研究。方法：使用64个电极的扩展记录剪辑，评估了10种刺激条件（睁眼和闭眼的5种闪光强度）的P2效果。结果：在一系列刺激强度范围内，最佳记录位点（O2）产生了最可靠的延迟和幅度。闪光强度不影响P2延迟或幅度。通过闭合的眼睑传递的闪光产生了闪光VEP，但是通过睁开的眼睛传递产生了缺少闪光P2成分的图案VEP。结论：这解释了某些实验室无法睁开眼睛复制AD组中P2延迟的原因。重要性：最佳闪光VEP条件包括闭眼和从O2记录。闪光强度并不重要。

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