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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Maturation processes in automatic change detection as revealed by event-related brain potentials and dipole source localization: significance for adult AD/HD.
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Maturation processes in automatic change detection as revealed by event-related brain potentials and dipole source localization: significance for adult AD/HD.

机译：事件相关的脑电势和偶极子源定位揭示了自动变化检测中的成熟过程：对成人AD / HD的意义。

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摘要

Mismatch negativity (MMN) is an event-related potential reflecting automatic attention-related information processing marking the detection of auditory change. The bilateral scalp distribution develops by 14 years of age, and is elicited with adult latencies by 17 years. But consistent with reports of continued brain maturation after adolescence, we show here that features of the temporal and frontal lobe dipole sources also continue to develop in the third decade of life. This has consequences for studies of the developmental course of MMN anomalies, from childhood into adulthood, in attention-deficit/hyperactivity disorder. Two groups of healthy subjects with mean ages of 17 and 30 years were presented with a 3-tone auditory oddball. The duration-deviant MMN was recorded during attention to a visual discrimination (auditory-passive condition) and an active auditory discrimination. MMN amplitudes were smaller in the older subjects and the MMN lasted longer over the right hemisphere. Latencies and moments of the four dipoles in the temporal and frontal lobes did not distinguish the two subject-groups. But both temporal lobe sources were located significantly more ventrally and further left in the young adult than in the adolescent subjects. The left cingular source moved posteriorly and the right inferior frontal source moved antero-medially in the older subjects. Brain development in the third decade may cause the two frontal sources to move apart on the rostro-caudal axis but the temporal lobe sources to move left on the lateral and down on the dorsoventral axes. Thus special care is necessary in interpreting putative dysfunctional neurobiological changes in developmental attention-deficit disorders where as-yet-unspecified sub-groups may show a late developmental lag, partial lag, or no lag at all, associated with other impairments.
机译：失配否定性（MMN）是与事件相关的电位，反映了与注意有关的自动信息处理，标志着对听觉变化的检测。双边头皮分布在14岁时发展，到成年潜伏期将在17岁时引起。但是，与青春期后大脑持续成熟的报道一致，我们在这里表明颞叶和额叶偶极子源的特征在生命的第三个十年中也继续发展。这对于研究注意力缺陷/多动障碍中从儿童期到成年期的MMN异常的发展过程具有影响。两组平均年龄分别为17和30岁的健康受试者接受了3音听觉异响测试。在注意视觉辨别力（听觉－被动状态）和主动听觉辨别力的过程中记录了持续时间不一致的MMN。在年龄较大的受试者中，MMN幅度较小，MMN在右半球的持续时间更长。颞叶和额叶中的四个偶极子的潜伏和矩不能区分这两个对象组。但是，与青春期受试者相比，年轻成年人中两个颞叶来源的腹侧位置明显更远，并且位置更远。在年龄较大的受试者中，左扣带源向后移动，右下额叶源向前-内侧移动。在第三个十年中，大脑的发育可能导致两个额叶源在胸尾轴上分开，而颞叶源在侧腹轴上向左移动而在背腹轴上向下移动。因此，在解释发育注意缺陷障碍中假定的功能失调的神经生物学变化时，需要特别注意，其中尚未确定的亚组可能显示出发育迟滞，部分迟缓或根本没有迟滞，并伴有其他障碍。

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