首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Thalamocortical theta coherence in neurological patients at rest and during a working memory task.
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Thalamocortical theta coherence in neurological patients at rest and during a working memory task.

机译:神经系统患者在休息和工作记忆期间的丘脑皮质相干性。

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We simultaneously recorded the local field potential (LFP) in the thalamus and the electroencephalogram (EEG) on the scalp of 5 patients suffering from neurogenic pain, epilepsy and movement disorders. In an earlier study [], we have investigated the slowing of EEG and the high thalamocortical coherence in the framework of thalamocortical dysrhythmia, the common underlying pathophysiology. The current study focuses on the effects of different cognitive conditions. When patients rested with eyes closed, a theta peak dominated the EEG spectra. The peak height was reduced upon opening the eyes, reminiscent of the classical alpha blocking. This peak reduction also appeared in the thalamic LFP recording. When patients activated their working memory by counting backwards, the theta peak increased in scalp EEG or in the LFP recorded in thalamic nuclei VA/VL. The coherence estimates between EEG and LFP ranged between 21% and 76% for different patients and cognitive conditions (mean: 50%). The involvement of both cortex and thalamus in working memory and the high thalamocortical coherence underline, in addition to cortico-cortical interactions, the importance of thalamocortical modules in the generation of higher cognitive functions.
机译:我们同时记录了5例患有神经源性疼痛,癫痫和运动障碍的患者的丘脑局部磁场(LFP)和脑电图(EEG)。在较早的研究中,我们研究了在常见的病理生理机制丘脑皮层心律不齐的框架内脑电图的减慢和丘脑皮层的高连贯性。当前的研究集中于不同认知条件的影响。当患者闭眼休息时,θ峰占主导地位。睁开眼睛后,峰高降低了,这让人想起了经典的alpha阻塞。该峰减少也出现在丘脑LFP记录中。当患者通过倒数启动工作记忆时,头皮脑电图或丘脑核VA / VL中记录的LFP中的theta峰增加。对于不同的患者和认知状况,EEG和LFP之间的一致性估计在21%到76%之间(平均:50%)。皮层和丘脑均参与工作记忆,并具有高丘脑皮层连贯性,这不仅说明了皮层与皮层的相互作用,还说明了丘脑皮层模块在产生更高认知功能中的重要性。

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