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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Effects of imipramine hydrochloride on the EEG of children with Attention-Deficit/Hyperactivity Disorder who are non-responsive to stimulants.
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Effects of imipramine hydrochloride on the EEG of children with Attention-Deficit/Hyperactivity Disorder who are non-responsive to stimulants.

机译：盐酸丙咪嗪对对兴奋剂无反应的注意力缺陷/多动障碍儿童的脑电图的影响。

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Although stimulant medications are the most commonly-used treatments for Attention-Deficit/Hyperactivity Disorder (AD/HD), as many as 20% of treated children do not respond clinically to stimulants. One non-stimulant medication that has been widely used when the stimulants fail is a tricyclic antidepressant, imipramine hydrochloride. This study investigated the effects of imipramine on the EEG of children with AD/HD who were poor responders to dexamphetamine and ritalin, but who showed clinical improvement on a six month trial of imipramine. An initial pre-medication EEG was recorded during an eyes-closed resting condition, with data Fourier transformed to provide absolute and relative power estimates for the delta, theta, alpha and beta bands. A second EEG was recorded at the end of the imipramine trial. Compared to controls, the unmedicated AD/HD children had significant global increases in absolute and relative theta, with decreased global absolute and relative alpha, increased posterior relative delta, and decreased posterior absolute beta. No change in the EEG was found as a result of administering the medication. These results suggest that good responders to imipramine have an underlying EEG abnormality different from that in children who respond to the stimulants, and that an initial pre-treatment EEG may be useful in selecting a trial medication. However, as no change in the EEG was found with imipramine, it is unlikely that the EEG will be useful in evaluating responsivity to this medication.
机译：尽管兴奋剂是注意力不足/多动症（AD / HD）的最常用治疗方法，但多达20％的治疗儿童对兴奋剂没有临床反应。当刺激剂失效时已被广泛使用的一种非刺激性药物是三环抗抑郁药盐酸丙咪嗪。这项研究调查了丙咪嗪对AD / HD儿童的脑电图的影响，这些儿童对右旋苯丙胺和利他林的反应较差，但在为期六个月的丙咪嗪试验中显示出临床改善。在闭眼休息状态下记录最初的用药前脑电图，对数据进行傅立叶变换，以提供δ，θ，α和β谱带的绝对和相对功效估计值。在丙咪嗪试验结束时记录了第二个脑电图。与对照组相比，未经药物治疗的AD / HD儿童的绝对和相对θ总体显着增加，总体绝对和相对α值降低，后相对δ增加，后绝对β值降低。用药未发现脑电图发生变化。这些结果表明，对丙咪嗪有良好反应者的潜在脑电图异常与对兴奋剂有反应的儿童有所不同，并且初始治疗前脑电图对于选择试验药物可能有用。但是，由于用丙咪嗪未发现脑电图有任何变化，因此脑电图不太可能用于评估对该药物的反应性。

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