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首页> 外文期刊>Investigative radiology >Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in yucatan miniswine.
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Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in yucatan miniswine.

机译：尤加坦小型猪中颈动脉粥样硬化的Gadofluorine增强磁共振成像。

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OBJECTIVE: The aim of this study was to determine whether gadofluorine, a paramagnetic magnetic resonance imaging (MRI) contrast agent, selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. METHODS: Atherosclerotic plaques were induced in the left carotid arteries (LCA) of Yucatan miniswine (n=3) by balloon denudation and high cholesterol diet. T1-weighted MRI was performed before and 24 hours after gadofluorine injection (at a dose of 100 micromol/kg) to assess the enhancement of the balloon-injured LCA wall relative to healthy, uninjured right carotid artery (RCA) wall. Histopathology was performed to verify the presence and composition of the atherosclerotic plaques imaged with MRI. RESULTS: Gadofluorine was found to enhance LCA atherosclerotic lesions relative to RCA wall by 21% (P<0.025) 24 hours after contrast injection. Enhancement of healthy LCA wall relative to healthy RCA wall was not observed. CONCLUSION: Gadofluorine selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. Gadofluorine appears to be a promising MR contrast agent for detection of atherosclerotic plaques in vivo.
机译：目的：本研究的目的是确定顺磁共振成像（MRI）造影剂加多氟汀是否能选择性增强尤卡坦微型猪的颈动脉粥样硬化斑块。方法：通过气球剥脱术和高胆固醇饮食在尤卡坦微型猪（n = 3）的左颈动脉（LCA）中诱发动脉粥样硬化斑块。 T1加权MRI在注射g氟（100 mol / kg剂量）之前和之后24小时进行，以评估相对于健康，未受伤的右颈动脉（RCA）壁，球囊损伤的LCA壁的增强。进行了组织病理学检查以证实用MRI成像的动脉粥样硬化斑块的存在和组成。结果：对比注射后24小时，发现加多氟汀相对于RCA壁可使LCA动脉粥样硬化病变增强21％（P <0.025）。相对于健康RCA壁，未观察到健康LCA壁的增强。结论：加多氟精选择性地增强了尤卡坦微型猪的颈动脉粥样硬化斑块。 ado荧光似乎是用于体内动脉粥样硬化斑块检测的有前景的MR造影剂。

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