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首页> 外文期刊>Investigative radiology >Mitral annular shape, size, and motion in normals and in patients with cardiomyopathy: evaluation with computed tomography.
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Mitral annular shape, size, and motion in normals and in patients with cardiomyopathy: evaluation with computed tomography.

机译：正常人和心肌病患者的二尖瓣环形状，大小和运动：计算机断层扫描评估。

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OBJECTIVE: To assess prospectively, in healthy subjects and in patients with dilated cardiomyopathy (DCM) and hypertrophic obstructive cardiomyopathy (HOCM), the 3-dimensional (3D) shape, size, and motion of the mitral annulus (MA) using computed tomography (CT). MATERIALS AND METHODS: Twenty patients with no cardiac abnormalities (referred to as normals), 15 with DCM, and 15 with HOCM as determined by echocardiography underwent contrast-enhanced, retrospectively electrocardiography (ECG)-gated 64-slice CT of the heart. The MA was manually segmented in 10% steps of the RR interval with dedicated 3D software employing the point-wrap algorithm. The MA shape, area size, change of the MA area, and apicobasal MA motion throughout the cardiac cycle was determined and compared between the groups. Intercommissural distances were measured with CT and compared with findings during surgery in 9 patients undergoing ring annuloplasty. RESULTS: The MA was nonplanar in all phases and subjects, being largest in diastole and smallest in systole. The MA area was significantly (P < 0.001) larger in patients with DCM (11.5 +/- 4.1 cm/m) as compared with normals (5.5 +/- 0.9 cm/m) and HOCM (4.7 +/- 0.9 cm/m). The change of MA area throughout the cardiac cycle was significantly (P < 0.017) smaller in patients with DCM (12.2 +/- 3.3%/m) as compared with normals (20.0 +/- 7.9%/m) and HOCM (20.5 +/- 7.7%/m). The mean apicobasal motion was significantly (P < 0.017) smaller in patients with DCM (2.2 +/- 1.0 mm/m) as compared with normals (3.6 +/- 0.8 mm/m) and HOCM (2.7 +/- 0.7 mm/m). Intercommissural distances as determined by CT showed a good correlation (r = 0.68, P < 0.05) with intraoperative measurements (mean difference, 0.44 mm; limits of agreement, -2.73-3.62 mm). CONCLUSION: Our study provides in vivo human data on the 3D shape, size, and motion of the MA in healthy subjects. Significant changes in size and motion of the MA were noted in patients with HOCM.
机译：目的：为了对健康受试者和扩张型心肌病（DCM）和肥厚性梗阻性心肌病（HOCM）的患者进行前瞻性评估，使用计算机断层摄影术（3D）对二尖瓣环（MA）的3维（3D）形状，大小和运动进行评估（ CT）。材料与方法：20例无心脏异常的患者（称为正常人），由超声心动图确定的15例DCM和15例HOCM患者接受了对比增强的回顾性心电图（ECG）门控心脏64层CT检查。使用专用的3D软件采用点套算法，以RR间隔的10％步长对MA进行了手动分段。确定并比较两组之间的MA形状，面积大小，MA面积的变化以及整个心动周期的apapobasal MA运动。使用CT测量了宫腔间距离，并将其与9例接受环形瓣环成形术的患者在手术期间的发现进行了比较。结果：MA在所有阶段和受试者均非平面，舒张期最大，收缩期最小。与正常人（5.5 +/- 0.9 cm / m）和HOCM（4.7 +/- 0.9 cm / m）相比，DCM（11.5 +/- 4.1 cm / m）患者的MA面积明显更大（P <0.001） ）。与正常人（20.0 +/- 7.9％/ m）和HOCM（20.5 +）相比，DCM（12.2 +/- 3.3％/ m）患者整个心动周期的MA面积变化明显较小（P <0.017） /-7.7％/ m）。与正常人（3.6 +/- 0.8 mm / m）和HOCM（2.7 +/- 0.7 mm / m）相比，DCM（2.2 +/- 1.0 mm / m）患者的平均pic突运动明显较小（P <0.017） m）。通过CT确定的术中距离与术中测量值之间具有良好的相关性（r = 0.68，P <0.05）（平均差异为0.44 mm;一致极限为-2.73-3.62 mm）。结论：我们的研究提供了有关健康受试者MA的3D形状，大小和运动的体内人类数据。在HOCM患者中，MA的大小和运动发生了显着变化。

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