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首页> 外文期刊>Investigative radiology >Intraindividual in vivo comparison of gadolinium contrast agents for pharmacokinetic analysis using dynamic contrast enhanced magnetic resonance imaging.
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Intraindividual in vivo comparison of gadolinium contrast agents for pharmacokinetic analysis using dynamic contrast enhanced magnetic resonance imaging.

机译：使用动态对比增强磁共振成像对of对比剂进行药动学分析的个体内体内比较。

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摘要

PURPOSE: To compare the intraindividual differences of dynamic signal characteristics for 3 gadolinium chelates (gadopentetate dimeglumine [Gd-DTPA], gadodiamide [Gd-DTPA-BMA], and gadobenate dimeglumine [Gd-BOPTA]) using dynamic contrast enhanced magnetic resonance (MR) imaging (DCE-MRI) with a preclinical beagle model at 7 Tesla. METHOD AND MATERIALS: Seven beagles were scanned 3 times each with a 7-day interval between the scans on a 7T whole body MRI system (Achieva, Philips) using a T/R head coil. Three different Gd contrast agents including Gd-DTPA, Gd-DTPABMA, and Gd-BOPTA were injected in a randomized order with a power injector (Spectris, MedRad, Indianola, PA) using dose of 0.1 mmol/kg body weight and flow rate of 0.06 mL/s. During image acquisition and data analysis, the identity of the specific contrast agent used for each examination was blinded. A 3D RF-spoiled fast field echo sequence was used for dynamic scans with in-plane spatial resolution 0.47 x 0.47 mm(2), temporal resolution of 9.5 seconds, and a total of 60 time points. Regions of interest were drawn within the carotid arteries and muscle tissue to determine semiquantitative parameters including maximum enhancement ratio, area under the signal enhancement curve over 90 seconds after contrast injection (AUC_90), time to maximum signal enhancement (T(max)), and washout_score. Additionally, quantitative pharmacokinetic parameters were measured in muscle tissues by applying 3 separate 2-compartment models; (1) artery input function (AIF) based Tofts model, (2) Brix model without AIF, and (3) AIF decomposed refined Brix model. RESULTS: Gd-BOPTA produced higher signal to noise ratio on postcontrast T1- weighted images than the other 2 Gd based contrast agents at 7T. Quantitatively, Gd-BOPTA provided a significantly higher maximum enhancement ratio (P < 0.01), AUC_90 (P < 0.01) and washout_score (P < 0.01) in beagle musculature and cranial vasculature compared with both Gd-DTPA and Gd-DTPA-BMA. Among all the quantitative pharmacokinetic parameters, only the exchange rate constants (kep) calculated from these 3 models did not show a significant difference among the various contrast agents. CONCLUSIONS: Gd chelate containing MR contrast agents can be used at 7T for DCEMRI. Gd-BOPTA demonstrates stronger signal enhancement than standard Gd chelates, in concordance with the results of studies at lower fields. The observed enhancement characteristics for the 3 contrast agents demonstrate that the pharmacokinetic parameter kep is more robust in various models using DCE-MRI than the other pharmacokinetic parameters. This information is important relative to multisite clinical trials and long-term clinical studies that often use several different contrast agents and different models.
机译：目的：比较使用动态对比增强磁共振（MR）技术分析的三种g螯合物（g戊二酸二丁胺[Gd-DTPA]，g二酰胺[Gd-DTPA-BMA]和g丙二胺[Gd-BOPTA]）的动态信号特性的个体差异。 （7特斯拉临床前Beagle模型成像）（DCE-MRI）。方法和材料：在7T全身MRI系统（Achieva，Philips）上，使用T / R头线圈，对7只小猎犬进行了3次扫描，每次扫描间隔7天。用动力注射器（Spectris，MedRad，印第安纳州，宾夕法尼亚州）以0.1 mmol / kg体重的剂量和流速以随机顺序随机注射三种不同的Gd造影剂，包括Gd-DTPA，Gd-DTPABMA和Gd-BOPTA。 0.06毫升/秒在图像采集和数据分析过程中，每次检查所使用的特定造影剂的身份均不明确。一个3D RF损坏的快速场回波序列用于平面空间分辨率为0.47 x 0.47 mm（2），时间分辨率为9.5秒和总共60个时间点的动态扫描。在颈动脉和肌肉组织内绘制感兴趣的区域，以确定半定量参数，包括最大增强率，对比剂注射后90秒内信号增强曲线下的面积（AUC_90），达到最大信号增强的时间（T（max））和washout_score。此外，通过应用3个独立的2室模型，在肌肉组织中测量了定量的药代动力学参数。 （1）基于动脉输入功能（AIF）的Tofts模型，（2）不具有AIF的糖度模型，以及（3）AIF分解的精制糖度模型。结果：在7T时，Gd-BOPTA在对比后T1加权图像上产生的信噪比高于其他2种基于Gd的造影剂。在数量上，与Gd-DTPA和Gd-DTPA-BMA相比，Gd-BOPTA在比格犬肌肉和颅血管中的最大增强率（P <0.01），AUC_90（P <0.01）和洗脱分数（P <0.01）明显更高。在所有定量药代动力学参数中，只有从这3个模型计算出的汇率常数（kep）在各种造影剂之间没有显示出显着差异。结论含MR造影剂的Gd螯合物可在7T时用于DCEMRI。与在较低领域的研究结果相一致，Gd-BOPTA表现出比标准Gd螯合物更强的信号增强作用。观察到的3种造影剂的增强特性表明，在使用DCE-MRI的各种模型中，药代动力学参数kep比其他药代动力学参数更稳定。相对于经常使用几种不同的造影剂和不同模型的多站点临床试验和长期临床研究而言，此信息非常重要。

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