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首页> 外文期刊>Investigative radiology >Relaxivity of Gadopentetate Dimeglumine (Magnevist), Gadobutrol (Gadovist), and Gadobenate Dimeglumine (MultiHance) in human blood plasma at 0.2, 1.5, and 3 Tesla.
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Relaxivity of Gadopentetate Dimeglumine (Magnevist), Gadobutrol (Gadovist), and Gadobenate Dimeglumine (MultiHance) in human blood plasma at 0.2, 1.5, and 3 Tesla.

机译：加巴喷丁胺（Magnevist），加巴多罗尔（Gadovist）和加巴贝酸二甲胺（MultiHance）在人血浆中的特斯拉分别为0.2、1.5和3

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OBJECTIVES: We sought to determine the relaxivity and accurate relaxation rates of Gd-DTPA, Gd-BT-DO3A, and Gd-BOPTA at 0.2, 1.5, and 3 T in human blood plasma. MATERIALS AND METHODS: Contrast media concentrations between 0.01 and 16 mM in human plasma were used for relaxation measurements. The R1 and R2 relaxation rates and r1 and r2 relaxivities were determined. RESULTS: Gd-BOPTA produced the highest relaxation rates and relaxivities at all field strengths. The r1 and r2 values for Gd-BOPTA were 107-131% and 91-244% higher than for Gd-DTPA, respectively, and 72-98% and 82-166% higher than for Gd-BT-DO3A. Higher field strengths resulted in lower values of R1, R2, and r1 for all contrast agents tested and of r2 for Gd-DTPA and Gd-BT-DO3A. A linear dependence of R1 and R2 on concentration was found for Gd-DTPA and Gd-BT-DO3A and a nonlinear dependence for Gd-BOPTA for concentrations larger than 1 mM. The r1 and r2 relaxivity of Gd-BOPTA increased with decreasing concentration. CONCLUSIONS: Gd-BOPTA demonstrates the highest longitudinal r1 at all field strengths, which is ascribable to weak protein interaction. The R2/R1 ratio increases at higher field strength only for Gd-BOPTA, hence very short echo times are required for Gd-BOPTA to benefit from the higher longitudinal relaxivity.
机译：目的：我们试图确定人血浆中Gd-DTPA，Gd-BT-DO3A和Gd-BOPTA在0.2、1.5和3 T下的弛豫度和准确的弛豫率。材料与方法：使用人体血浆中0.01到16 mM的造影剂浓度进行弛豫测量。确定了R1和R2弛豫率以及r1和r2弛豫率。结果：Gd-BOPTA在所有场强下产生最高的弛豫率和弛豫度。 Gd-BOPTA的r1和r2值分别比Gd-DTPA高107-131％和91-244％，比Gd-BT-DO3A高72-98％和82-166％。较高的场强导致所有测试的造影剂的R1，R2和r1值降低，而Gd-DTPA和Gd-BT-DO3A的r2值降低。对于Gd-DTPA和Gd-BT-DO3A，发现R1和R2对浓度呈线性关系，对于浓度大于1 mM的对Gd-BOPTA具有非线性关系。 Gd-BOPTA的r1和r2弛豫度随浓度降低而增加。结论：Gd-BOPTA在所有场强下均显示出最高的纵向r1，这归因于弱的蛋白质相互作用。仅对于Gd-BOPTA，R2 / R1比率在较高的场强下才增加，因此Gd-BOPTA需要非常短的回波时间才能受益于较高的纵向弛豫性。

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