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首页> 外文期刊>Investigative radiology >Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325.
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Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325.

机译：物种依赖血浆蛋白结合和基于based的MRI造影剂MS-325的弛豫性。

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RATIONALE AND OBJECTIVES: We sought to determine whether there is a species dependence on plasma protein and serum album binding and/or relaxivity of the MR contrast agent MS-325. METHODS: Equilibrium binding of MS-325 to plasma proteins or purified serum albumin was determined as a function of chelate concentration. T1 and T2 values were determined at 0.47 and 1.41 T, and NMRD profiles were measured to determine the changes in relaxivity over varying field strengths from 0.002 to 1.2 T. RESULTS: The binding of MS-325 to either animal plasma or serum albumin plateaus at chelate concentrations less than 0.1 mM with human, pig, and rabbit plasmas showing maximum binding. Human and pig plasmas show the greatest observed relaxivity enhancement in the presence of MS-325. CONCLUSIONS: MS-325 exhibits increased relaxivity in blood plasma as the result of plasma protein binding. Binding ranged from 64% to 91% and was species dependent: human > pig approximately rabbit > dog approximately rat approximately mouse.
机译：理由和目的：我们试图确定一种物种是否对MR造影剂MS-325的血浆蛋白和血清白蛋白结合和/或松弛度有依赖性。方法：确定MS-325与血浆蛋白或纯化的血清白蛋白的平衡结合与螯合浓度的关系。在0.47和1.41 T下测定T1和T2值，并测量NMRD谱图以确定从0.002至1.2 T变化的场强下弛豫度的变化。结果：MS-325与动物血浆或血清白蛋白平台的结合在人，猪和兔血浆中的螯合剂浓度低于0.1 mM，显示出最大的结合力。在MS-325的存在下，人和猪的血浆显示出最大的弛豫性增强。结论：由于血浆蛋白结合，MS-325在血浆中表现出增加的松弛度。结合范围从64％到91％，并且是物种依赖性的：人>猪约兔>狗约大鼠约小鼠。

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