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首页> 外文期刊>Investigative radiology >Comparison of Gadolinium-BOPTA and Ferucarbotran-enhanced three-dimensional T1-weighted dynamic liver magnetic resonance imaging in the same patient.
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Comparison of Gadolinium-BOPTA and Ferucarbotran-enhanced three-dimensional T1-weighted dynamic liver magnetic resonance imaging in the same patient.

机译：patient-BOPTA和Ferucarbotran增强的三维T1加权动态肝脏磁共振成像在同一患者中的比较。

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摘要

OBJECTIVES: We sought to compare signal changes using Ferucarbotran and gadobenate dimeglumine (Gd-BOPTA) in dynamic 3D T1-weighted (T1w) GRE imaging of the liver. MATERIAL AND METHODS: Thirty patients were prospectively included in the study. All patients underwent 2 high-field magnetic resonance (MR) examinations: first with Gd-BOPTA (Gd) and then after a mean interval of 4 days with ferucarbotran (Feru). Dynamic MRI was obtained with a 3D T1w GRE sequence (TR 6.33, TE 2.31, flip angle 20 degrees ). Contrast enhanced scans were assessed before intravenous injection of the contrast agent (precontrast), and postcontrast during the arterial phase (30 seconds), portal venous phase (60 seconds), and equilibrium phase (120 seconds). The signal intensities (SIs) of liver, spleen, aorta, and portal vein were defined by region of interest measurements. Signal intensity changes (SICs) and percentage signal intensity change (PSIC) were calculated using the formulas SIC=(SI pre - SI post)/SI pre and PSIC=SIC x 100%. RESULTS: Positive signal enhancement was observed after intravenous injection of Feru during all dynamic measurements, whereas the mean SI values were lower compared with Gd. During the portal venous phase the mean SI of Gd was up to a factor of 2.1 higher (portal vein). The widest difference of SIC was observed during the equilibrium phase for liver parenchyma (Gd, 1.03; Feru, 0.24). The dynamic signal courses were similar for liver, portal vein and aorta. Different signal courses were obtained for the spleen. CONCLUSIONS: Feru-enhanced T1w dynamic images demonstrated significant signal increases for liver, vessels, and spleen but overall lower signal intensities than Gd-BOPTA. The dynamic signal courses of ferucarbotran were similar to that of Gd-BOPTA during ll perfusion phases except in the spleen. Thus, it may be possible to detect typical enhancement pattern of focal liver lesions with Feru-enhanced dynamic T1w MRI.
机译：目的：我们试图比较在动态3D T1加权（T1w）肝脏GRE成像中使用Ferucarbotran和gadobenate dimeglumine（Gd-BOPTA）的信号变化。材料与方法：前瞻性纳入了30例患者。所有患者均接受了2次高场磁共振（MR）检查：首先接受Gd-BOPTA（Gd）治疗，然后平均间隔4天接受Ferucarbotran（Feru）治疗。使用3D T1w GRE序列（TR 6.33，TE 2.31，翻转角20度）获得动态MRI。在静脉注射造影剂之前（对比前），以及在动脉期（30秒），门静脉期（60秒）和平衡期（120秒）进行对比后，评估对比增强扫描。肝脏，脾脏，主动脉和门静脉的信号强度（SI）通过感兴趣区域的测量来定义。使用公式SIC =（SI pre-SI post）/ SI pre和PSIC = SIC x 100％计算公式来计算信号强度变化（SIC）和百分比信号强度变化（PSIC）。结果：在所有动态测量过程中，静脉注射Feru后均观察到阳性信号增强，而平均SI值低于Gd。在门静脉期，Gd的平均SI升高了2.1倍（门静脉）。在肝实质的平衡阶段观察到SIC的最大差异（Gd，1.03; Feru，0.24）。肝，门静脉和主动脉的动态信号过程相似。脾脏获得了不同的信号过程。结论：Feru增强的T1w动态图像显示肝脏，血管和脾脏的信号明显增加，但总体信号强度低于Gd-BOPTA。除脾脏外，ferucarbotran在ll灌注阶段的动态信号过程与Gd-BOPTA相似。因此，用Feru增强的动态T1w MRI可以检测出局灶性肝病灶的典型增强模式。

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