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首页> 外文期刊>Investigative radiology >Ultra-low-dose, time-resolved contrast-enhanced magnetic resonance angiography of the carotid arteries at 3.0 tesla.
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Ultra-low-dose, time-resolved contrast-enhanced magnetic resonance angiography of the carotid arteries at 3.0 tesla.

机译:3.0特斯拉颈动脉的超低剂量,时间分辨的对比增强磁共振血管造影。

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PURPOSE: To determine whether time-resolved magnetic resonance angiography (TR-MRA) with ultra-low-dose gadolinium chelate (1.5-3.0 mL) can reliably detect or rule out hemodynamically significant disease in the carotid-vertebral artery territory. MATERIALS AND METHODS: Hundred consecutive patients (62 women, 38 men, mean age = 56.6 years) underwent both TR-MRA and standard high-resolution contrast-enhanced magnetic resonance angiography (CE-MRA), having been randomized to 1 of 2 groups; group A receiving a contrast dose of 1.5 mL for TR-MRA and group B receiving 3.0 mL. For scoring purposes the arterial system was divided into 21 segments. All TR-MRA and CE-MRA studies were blindly assessed by 2 radiologists for overall image quality, segmental arterial visualization, grading of arterial stenosis/occlusion, and incidence and severity of artifact. TR-MRA findings were directly compared with those of the corresponding CE-MRA examinations. RESULTS: Group A TR-MRA studies were of significantly inferior overall image quality compared with those of the corresponding CE-MRA examinations (P = 0.01 for both observers). In group B, overall image quality was similar for TR-MRA and single-phase CE-MRA examinations. On a segmental basis, a higher number of "insufficient quality" segments were identified in group A TR-MRA studies than in group B. A similar reduction in the incidence of artifacts was observed for group B relative to group A TR-MRA studies. Both groups A and B TR-MRA studies were of high specificity, negative predictive values, and accuracy (>97%). CONCLUSION: Ultra-low dose TR-MRA may be performed with 3 mL of gadolinium chelate with preservation of overall image quality and arterial segmental visualization relative to single phase CE-MRA, whereas a 1.5 mL contrast dose is associated with more suboptimal studies. Nonetheless, even at doses as low as 1.5 mL, TR-MRA can exclude arterial stenosis or occlusion.
机译:目的:确定时间分辨磁共振血管造影(TR-MRA)与超低剂量g螯合物(1.5-3.0 mL)能否可靠地检测或排除颈椎-椎动脉区域的血液动力学显着疾病。材料与方法:连续100例患者(62名女性,38名男性,平均年龄= 56.6岁)接受了TR-MRA和标准高分辨率对比增强磁共振血管造影(CE-MRA)检查,被随机分为2组中的1组; A组接受TR-MRA的对比剂量为1.5 mL,B组接受对比剂为3.0 mL。为了计分,将动脉系统分为21个部分。两名放射科医生对所有TR-MRA和CE-MRA研究进行了盲目评估,以评估整体图像质量,节段性动脉可视化,动脉狭窄/闭塞的等级以及伪影的发生率和严重性。将TR-MRA的发现与相应的CE-MRA检查直接进行比较。结果:与相应的CE-MRA检查相比,A组TR-MRA研究的整体图像质量明显较差(两位观察者的P = 0.01)。在B组中,TR-MRA和单相CE-MRA检查的总体图像质量相似。基于细分,在A组TR-MRA研究中发现的“质量不足”区段数量要高于B组。与A组TR-MRA研究相比,B组的假象发生率也有类似的降低。 A组和B组TR-MRA研究均具有高特异性,阴性预测值和准确性(> 97%)。结论:相对于单相CE-MRA,可使用3 mL che螯合物进行超低剂量TR-MRA,相对于单相CE-MRA,可保持整体图像质量和动脉节段可视化,而1.5 mL对比剂量与更次优的研究相关。尽管如此,即使在低至1.5 mL的剂量下,TR-MRA也可以排除动脉狭窄或闭塞。

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