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首页> 外文期刊>International journal of surgical pathology >Well-Differentiated Follicular Patterned Tumors of the Thyroid With High-Grade Features Can Metastasize in the Absence of Capsular or Vascular Invasion: Report of a Case
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Well-Differentiated Follicular Patterned Tumors of the Thyroid With High-Grade Features Can Metastasize in the Absence of Capsular or Vascular Invasion: Report of a Case

机译：高度分化的甲状腺分化良好的滤泡状肿瘤可在无胶囊或血管浸润的情况下转移：一例报告

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摘要

We report a case of an encapsulated, noninvasive, follicular thyroid neoplasia with high-grade features in a 59-year-old man who developed multiple metastases. The 5-cm lesion was originally categorized by thyroid fine-needle aspiration as suspicious for a follicular lesion and as a follicular adenoma on the subsequent hemithyroidectomy specimen. The high-grade features were represented by foci of solid, trabecular, and insular pattern (10% of the tumor), necrosis (< 5% of the tumor), and up to 14 mitoses per 10 high-power fields in the solid areas. No immunohistochemical and molecular markers associated to thyroid malignancy were observed. Although encapsulated noninvasive follicular tumors are usually regarded as benign lesions that never metastasize or recur, our case was characterized mainly by an elevated number of mitoses, and the patient progressed to widespread metastatic disease. This uncommon lesion should most likely be considered as an early form of poorly differentiated thyroid carcinoma with a dismal prognosis.
机译：我们报告了一个囊性，无创性，滤泡性甲状腺肿瘤的病例，该肿瘤在一个发生多处转移的59岁男性中具有高度特征。最初通过甲状腺细针穿刺术将5 cm病变归类为可疑为滤泡性病变，并在随后的甲状腺切除术标本中归类为滤泡性腺瘤。高等级特征由实心区域，小梁和岛状模式（占肿瘤的10％），坏死（占肿瘤的5％）和每10个高倍视野中的14个有丝分裂区域代表。没有观察到与甲状腺恶性肿瘤相关的免疫组化和分子标记。尽管包囊性非侵入性滤泡性肿瘤通常被认为是从未转移或复发的良性病变，但本病例的主要特征是有丝分裂数量增加，患者逐渐发展成广泛的转移性疾病。这种罕见的病变最有可能被认为是分化不良的甲状腺癌的早期形式，预后不良。

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