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首页> 外文期刊>International journal of surgical pathology >Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma
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Protein Expression of MMP-2 and MT1-MMP in Actinic Keratosis, Squamous Cell Carcinoma of the Skin, and Basal Cell Carcinoma

机译：MMP-2和MT1-MMP在光化性角化病，皮肤鳞状细胞癌和基底细胞癌中的蛋白表达

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摘要

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.
机译：鳞状细胞癌（SCC）和基底细胞癌（BCC）是2种皮肤肿瘤，具有不同的侵袭和转移潜能。光化性角化病（AK）是SCC的前体病变。进行免疫组织化学以评估BCC（n = 29），SCC（n = 12）和AK（n = 13）样品中MMP-2和MT1-MMP的表达。阳性细胞与总细胞的比例用于定量染色。在P <.05水平下考虑了统计学显着性。我们发现，与BCC相比，SCC的肿瘤基质和实质中MMP-2的表达更高。该蛋白的表达在SCC及其前体光化性角化病之间也相似，并且与低风险BCC相比，其在高风险BCC的基质中更高。 MT1-MMP是MMP-2的激活剂，在所有组中均类似表达。我们的结果表明，MMP-2表达可能有助于SCC和BCC中所见的独特侵袭性模式。

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