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首页> 外文期刊>International journal of surgical pathology >Malignant Melanoma With Osteoclast-Like Differentiation
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Malignant Melanoma With Osteoclast-Like Differentiation

机译：具有破骨细胞样分化的恶性黑色素瘤

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摘要

Osteoclast-like giant cells are frequently encountered in nonskeletal malignancies; however, the evidence to date suggests that they represent a tissue response to the lesion rather than neoplastic differentiation. We describe a case of metastatic melanoma demonstrating osteoclast-like differentiation in the lung. The lung nodule was diagnosed as a metastatic melanoma by histological features and confirmed by immunohistochemistry. Resection specimen showed numerous multinucleated giant cells exhibiting osteoclast-like morphology dispersed throughout the lesion. Both the neoplastic melanocytes and giant cells were reactive for HMB-45, Melan-A, and S100. In addition, the multinucleated neoplastic giant cells were also reactive for the monocyte/macrophage lineage markers CD68 and CD163, and alkaline phosphatase, an enzyme present in normal osteoclasts. The neoplastic melanocytes and the multinucleated neoplastic giant cells were also reactive for microphthalmia-associated transcription factor, a protein required for the development of both melanocytes and osteoclasts. Collectively, a co-expression of monocyte/macrophage markers along with melanocytic markers and alkaline phosphatase in the multinucleated neoplastic giant cells in metastatic melanoma suggest that malignant melanocytes are capable of differentiating into osteoclast-like cells and consequently aid invasion into various structures and eliciting the aggressive behavior.
机译：非骨骼恶性肿瘤中经常遇到破骨细胞样巨细胞。然而，迄今为止的证据表明它们代表了对病变的组织反应，而不是肿瘤分化。我们描述了一例转移性黑色素瘤，表明肺中有破骨细胞样分化。通过组织学特征将肺结节诊断为转移性黑色素瘤，并通过免疫组织化学证实。切除标本显示许多多核巨细胞，散在整个病变处，显示出破骨细胞样形态。肿瘤黑素细胞和巨细胞均对HMB-45，Melan-A和S100具有反应性。另外，多核赘生物巨细胞也对单核细胞/巨噬细胞谱系标记CD68和CD163以及碱性磷酸酶（正常破骨细胞中存在的一种酶）具有反应性。肿瘤性黑素细胞和多核肿瘤性巨细胞对小眼症相关转录因子也有反应，而转录因子是黑素细胞和破骨细胞发育所必需的蛋白质。集体地，在转移性黑素瘤的多核赘生物巨细胞中单核细胞/巨噬细胞标志物与黑素细胞标志物和碱性磷酸酶的共表达表明，恶性黑素细胞能够分化为破骨细胞样细胞，从而帮助其侵入各种结构并引发攻击行为。

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