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首页> 外文期刊>International journal of surgical pathology >Unsuspected Xp11 Translocation Renal Neoplasm Associated With Contralateral Clear Cell Carcinoma
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Unsuspected Xp11 Translocation Renal Neoplasm Associated With Contralateral Clear Cell Carcinoma

机译：Xp11易位肾肿瘤与对侧透明细胞癌相关联。

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摘要

In this report, we present for the first time the coexistence of a conventional renal cell carcinoma (RCC) and an undefined Xp11 translocation renal neoplasm in distinct kidneys, which was difficult to definitively classify as either carcinoma or PEComa (perivascular epithelioid cell tumor). While one of the tumors showed the morphological and immunohistochemical features of clear RCC, the other had an unusual morphology with a prominent nested pattern. Microscopically this tumor showed nests of cells with clear and eosinophilic cytoplasm and nuclei with prominent nucleoli; some hyaline globules were evident. Immunohistochemical panel showed negativity for cytokeratin-pan, cytokeratin-7, PAX8, and CD10 but positive immunostaining for cathepsin K, racemase, Melan-A, and TFE3. A subsequent, metaphase, dual-color fluorescence in situ hybridization confirmed the Xp11 translocation. Attention should be paid to the routine immunohistochemical profile that, in case of negativity of specific RCC markers, may suggest an Xp11 translocation renal tumor. The addition of TFE3 can easily identify the specific subtype.
机译：在本报告中，我们首次提出了常规肾细胞癌（RCC）和未定义的Xp11易位性肾肿瘤在不同肾脏中的共存，很难明确地将其归类为癌或PEComa（血管周上皮样细胞瘤）。尽管其中一个肿瘤表现出清晰的RCC的形态和免疫组织化学特征，但另一个肿瘤则具有异常的形态和突出的嵌套模式。镜下可见该肿瘤巢内有清晰的嗜酸性细胞质和核仁突出的细胞核。有一些透明的小球。免疫组织化学检测结果显示细胞角蛋白泛，细胞角蛋白7，PAX8和CD10呈阴性，但组织蛋白酶K，消旋酶，Melan-A和TFE3呈阳性免疫染色。随后的中期双色荧光原位杂交证实了Xp11易位。应注意常规免疫组织化学分析，如果特异性RCC标记阴性，则可能提示Xp11易位性肾肿瘤。 TFE3的添加可以轻松识别特定的亚型。

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