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首页> 外文期刊>Investigative radiology >Acoustic properties of NC100100 and their relation with the microbubble size distribution.
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Acoustic properties of NC100100 and their relation with the microbubble size distribution.

机译：NC100100的声学特性及其与微泡尺寸分布的关系。

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摘要

RATIONALE AND OBJECTIVES: NC100100 is a contrast agent for medical imaging with ultrasonography consisting of stabilized gas microbubbles in an aqueous suspension. The objective of this article is to explore the acoustic properties of NC100100 and their relation with the microbubble size distribution. The results are used to motivate the choice of a suitable assay/dosage parameter for precise control of product efficacy. METHODS: The concentration and size distribution of microbubbles in > 50 preparations of NC100100 were determined by Coulter counting, and the acoustic attenuation and backscatter efficacy were determined for all samples. The in vivo efficacy of the product was investigated by harmonic imaging of the heart in a dog model. RESULTS: The results demonstrated that the attenuation and backscatter efficacy per microbubble volume vary strongly with size, showing distinct maxima with respect to microbubble diameter. Sizes for optimal attenuation per volume ranged from 2.6 to 5.8 microns, depending on ultrasound frequency. The contribution of the smaller end tail of the microbubble distribution was shown to be negligible. From the observed size dependency for the acoustic properties, the volume concentration of microbubbles was chosen as the assay/dosage parameter for NC100100. The accuracy of this parameter as a descriptor of product efficacy was demonstrated by precise, linear relations between volume, concentration, and attenuation/backscatter. In comparison, the correlation between the microbubble number and acoustic properties was not significant. Results from the in vivo study showed a precise, linear relation between injected microbubble volume and the observed in vivo efficacy. CONCLUSIONS: The acoustic properties of NC100100 are dependent on microbubble size. The observed batch-to-batch variance in the acoustic properties of the product may be fully explained by variation in concentration and size. Microbubble volume is a more precise predictor of in vitro/in vivo efficacy than microbubble number and consequently was chosen as the assay/dosage parameter for NC100100.
机译：理由和目的：NC100100是一种用于超声医学成像的造影剂，由在水性悬浮液中稳定的气体微气泡组成。本文的目的是探讨NC100100的声学特性及其与微气泡尺寸分布的关系。结果用于激励选择合适的测定/剂量参数以精确控制产品功效。方法：采用库尔特计数法测定了50多种NC100100制剂中微泡的浓度和大小分布，并测定了所有样品的声衰减和反向散射功效。通过在狗模型中心脏的谐波成像研究了该产品的体内功效。结果：结果表明，每个微气泡体积的衰减和反向散射功效随尺寸变化很大，相对于微气泡直径显示出明显的最大值。单位体积最佳衰减的大小在2.6到5.8微米之间，具体取决于超声频率。微泡分布的较小尾巴的贡献显示为可忽略的。从观察到的对声学特性的尺寸依赖性，选择微泡的体积浓度作为NC100100的测定/剂量参数。体积，浓度和衰减/反向散射之间的精确线性关系证明了该参数作为产品功效描述符的准确性。相比之下，微气泡数与声学特性之间的相关性并不显着。体内研究结果表明，注射的微气泡量与观察到的体内功效之间存在精确的线性关系。结论：NC100100的声学特性取决于微气泡的大小。可以通过浓度和尺寸的变化来充分解释所观察到的产品的声学特性之间的差异。微气泡体积比微气泡数量是更准确的体外/体内功效预测指标，因此被选作NC100100的测定/剂量参数。

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