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首页> 外文期刊>International journal of surgical pathology >Correlation of p63 protein expression with histological grade of meningiomas: An immunohistochemical study
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Correlation of p63 protein expression with histological grade of meningiomas: An immunohistochemical study

机译：p63蛋白表达与脑膜瘤组织学分级的相关性：一项免疫组织化学研究

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Prediction of tumor behavior in meningiomas based on morphological features alone remains difficult. Several immunohistochemical biomarkers have been proposed to assist conventional methods. However, no single immunohistochemical marker can unequivocally discriminate between benign and aggressive meningiomas. There is only 1 study available in the literature that correlates p63 expression with overall histological grade of the meningioma. The present study is undertaken to assess the correlation between p63 expression and histological grade of meningiomas. For this purpose, the authors studied and analyzed the immunohistochemical expression of p63 in 85 cases of meningioma, including WHO grade I (63), grade II (11), and grade III (11) cases. Correlation between histological grade and nuclear immunoreactivity to p63 antibody was performed. Furthermore, expression of p63 protein was correlated with short clinical follow-up and Ki-67 proliferation index. Among 85 patients analyzed, there were 61 women (71.7 %) and 24 men (28.2%) between 7 and 75 years old. Expression of p63 protein was found in 34.9% of grade I cases, but in grade II and III, 63.6% of cases each were immunoreactive. Correlation between histological grade and p63 immunoreactivity was significant (P =.02). p63-positive grade I meningiomas did not show elevated Ki-67 index. The present study contradicts earlier reports because there are a considerable number of grade I meningiomas that express p63. Although p63 expression is significantly associated with higher histological grade of meningiomas, it may not be considered as a sole biomarker to assess aggressive behavior of the tumor.
机译：仅基于形态学特征来预测脑膜瘤的肿瘤行为仍然很困难。已经提出了几种免疫组织化学生物标志物来辅助常规方法。但是，没有任何一种免疫组织化学标记可以明确地区分良性和侵袭性脑膜瘤。文献中只有1个研究将p63表达与脑膜瘤的整体组织学分级相关。本研究旨在评估p63表达与脑膜瘤组织学分级之间的相关性。为此，作者研究和分析了85例脑膜瘤患者中p63的免疫组织化学表达，其中包括WHO I级（63），II级（11）和III级（11）病例。进行了组织学等级与对p63抗体的核免疫反应性之间的相关性。此外，p63蛋白的表达与短期临床随访和Ki-67增殖指数相关。在分析的85位患者中，有7位至75岁的女性61位（71.7％），男性24位（28.2％）。 I级患者中有34.9％发现了p63蛋白的表达，而II级和III级患者中有63.6％的患者具有免疫反应性。组织学等级与p63免疫反应性之间的相关性显着（P = .02）。 p63阳性的I级脑膜瘤未显示Ki-67指数升高。本研究与早期报道相矛盾，因为存在大量表达p63的I级脑膜瘤。尽管p63表达与脑膜瘤的较高组织学等级显着相关，但它可能不被认为是评估肿瘤侵袭性的唯一生物标志物。

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