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首页> 外文期刊>The Journal of the South African Veterinary Association >The effects of firocoxib (PrevicoxsupTM/sup) in geriatric dogs over a period of 90 days.
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The effects of firocoxib (PrevicoxsupTM/sup) in geriatric dogs over a period of 90 days.

机译：氟罗昔布 （PrevicoxsupTM）/sup 在 90 天内对老年犬的影响。

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The long-term use of non-steroidal anti-inflammatory agents in geriatric dogs with osteoarthritis has not been well studied in veterinary medicine. This study evaluated the effects of firocoxib administered to dogs over 7 years of age for 90 days. Pain and lameness scores were evaluated by the owner weekly for the 1st month and then biweekly through to the end of the study, the veterinarian evaluated the dogs monthly. Serum chemistry, including urea, creatinine, alanine transferase, aspartate transaminase, bile acids and bilirubin, urine specific gravity and a urine dipstick, were performed at monthly intervals. Forty-five dogs were enrolled into the treatment group and 9 into the control group. A total of 33 dogs completed the trial in the treatment group and 8 in the control group. Lameness and pain scores were found to be significantly lower in the treated group from day 30 for most parameters evaluated. Bile acids (although not comparable to controls, with higher mean value and a high standard deviation in the control group; in addition the control group had increased bile acids at day 0) and urea (within normal reference range provided (WNL)) were significantly different in the treatment group between days 0 and 90. Urea (WNL) on days 30 and 90 and creatinine (WNL) on day 90 were significantly different between the control group and the treatment group. The most common adverse events reported were diarrhoea, vomition, dark faeces and anorexia. This study showed that firocoxib was effective in managing pain associated with osteoarthritis for 90 days. Despite the geriatric high-risk population used for this shady, minimal biochemical changes were seen and adverse drug events seen were in agreement with those previously reported.
机译：在患有骨关节炎的老年犬中长期使用非甾体抗炎药尚未在兽医学中得到充分研究。本研究评估了氟罗昔布对 7 岁以上狗 90 天的影响。主人在第 1 个月每周评估一次疼痛和跛行评分，然后每两周评估一次，直到研究结束，兽医每月评估一次狗。每月进行一次血清化学检查，包括尿素、肌酐、丙氨酸转移酶、天冬氨酸转氨酶、胆汁酸和胆红素、尿比重和尿试纸。治疗组有45只狗，对照组有9只狗。治疗组共有 33 只狗完成了试验，对照组共有 8 只狗完成了试验。从第 30 天开始，治疗组的跛行和疼痛评分显着降低，对于评估的大多数参数。胆汁酸（虽然不能与对照组相提并论，但对照组的平均值较高，标准偏差较高;此外，对照组在第0天时胆汁酸增加）和尿素（在提供的正常参考范围内（WNL））在治疗组中在第0天和第90天之间有显着差异。对照组和治疗组第30天和第90天的尿素（WNL）和第90天的肌酐（WNL）差异有统计学意义。报告的最常见的不良事件是腹泻、呕吐、深色粪便和厌食症。这项研究表明，氟罗昔可有效控制与骨关节炎相关的疼痛 90 天。尽管老年高危人群被用于这种阴暗，但观察到最小的生化变化，并且看到的药物不良事件与先前报道的一致。

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