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首页> 外文期刊>Iranian journal of public health. >Polymorphism in Exon 2 of CD1 Genes in Southwest of Iran
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Polymorphism in Exon 2 of CD1 Genes in Southwest of Iran

机译：伊朗西南部CD1基因第2外显子的多态性

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Abstract Background: The CD1 family is less variable transmembrane antigen presenting molecules related to the MHC molecules. CD1a and CD1e genes are the most polymorphic ones associated with autoimmune diseases. The aim was to better clarify the map of CD1 genes in Southwest Iranian normal population for implications in vaccine design. Methods: In this study we investigated the polymorphism of CD1a, CD1d and CD1e in 311 healthy individuals from Fars Province in Southwest of Iran by PCR-SSP method. Results: Six of individuals had homozygote CD1a 01/01 genotype and 248 had homozygote CD1a 02/02 genotype. CD1d was found to be monomorphic with all tested individuals showing CD1d 01/01 genotype. Hundred and eleven individuals had homozygote CD1e 01/01 genotype and 48 had homozygote CD1e 02/02 genotype. The frequencies of CD1a 01 and CD1a 02 alleles were 11% and 89% while the frequencies of CD1e 01 and CD1e 02 alleles were 60.1% and 39.9%, respectively. Consistent with previous reports on other genes, a high degree of similarity in CD1a and CD1e allelic distribution was observed between Southwest Iranians and other Indo-European populations. However, the allelic frequency of the CD1a and CD1e aEeles showed a significant difference from those of Chinese Han and She populations. Conclusion: These data are notable in the light of relatively recent genetic admixture along the Silk Road. Considering the significance of CD1 alleles in some autoimmune and infectious diseases and with the admixed nature of Iranian population, mapping the distribution of CD1e alleles in different regions of Iran can be useful in future designing of preventive and therapeutic vaccines.
机译：摘要背景：CD1家族是与MHC分子相关的可变性较小的跨膜抗原呈递分子。 CD1a和CD1e基因是与自身免疫性疾病相关的最多态的基因。目的是更好地阐明伊朗西南正常人群中CD1基因的图谱，以说明疫苗设计的意义。方法：本研究通过PCR-SSP方法研究了伊朗西南部法尔斯省的311名健康个体的CD1a，CD1d和CD1e多态性。结果：六个个体具有纯合子CD1a 01/01基因型，248个具有纯合子CD1a 02/02基因型。发现CD1d是单态的，所有测试的个体均显示CD1d 01/01基因型。一百一十一个人具有纯合子CD1e 01/01基因型，48个人具有纯合子CD1e 02/02基因型。 CD1a 01和CD1a 02等位基因的频率分别为11％和89％，而CD1e 01和CD1e 02等位基因的频率分别为60.1％和39.9％。与先前有关其他基因的报道一致，在西南伊朗人与其他印欧人群之间观察到了CD1a和CD1e等位基因分布的高度相似性。然而，CD1a和CD1e aEeles的等位基因频率与中国汉族和She族人群显示出显着差异。结论：鉴于“丝绸之路”沿线的近期遗传混杂，这些数据值得注意。考虑到CD1等位基因在某些自身免疫和传染性疾病中的重要性以及伊朗人口的混合性，绘制CD1e等位基因在伊朗不同地区的分布图可用于将来设计预防和治疗疫苗。

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