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首页> 外文期刊>Issues in comprehensive pediatric nursing. >Editorial: Data driven processes for assessing children's hospitals and units: Professor Alan Glasper discusses how children's nurses can enhance care delivery using pertinent data
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Editorial: Data driven processes for assessing children's hospitals and units: Professor Alan Glasper discusses how children's nurses can enhance care delivery using pertinent data

机译：社论：以数据为依据的评估儿童医院和单位的流程：艾伦·格拉斯珀（Alan Glasper）教授讨论了儿童护士如何使用相关数据来提高护理水平

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Background: Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll-like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy. Methods: We analyzed the role of functional single-nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow-band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis. Results: We found a significant relationship between TLR9-1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution. Conclusions: We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.
机译：背景：尽管已经确定了一些遗传预测因子，但对银屑病患者对紫外线B（UVB）光疗反应的预测主要取决于临床标准。 Toll样受体（TLR）已通过激活先天免疫系统参与了牛皮癣的发病过程。它们的多态性不仅可以调节牛皮癣的临床特征，还可以调节对治疗的反应。方法：我们分析了39例中度至重度牛皮癣患者中TLR2、5、4和9的功能性单核苷酸多态性（SNP）在对标准窄带UVB（NBUVB）治疗的临床反应中的作用。结果：我们发现TLR9-1486T / C SNP变体与对NBUVB光疗的更好反应之间存在显着关系。 TC和CC基因型患者比TT基因型患者表现出更高的银屑病面积和严重程度指数（PASI）改善。多元分析结果表明，光疗结束时归因于TRL9 SNP基因型的PASI改善的差异不取决于患者的照像类型，年龄，性别，体重指数，基础PASI或疾病进展。结论：我们描述了TLR9基因的功能性遗传变异，可能会影响对银屑病治疗的敏感性。遗传预测因子的搜索可能有助于银屑病患者的治疗选择和治疗方案的优化。

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