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A thermostable archaeal S-adenosylmethionine synthetase:a promising tool to improve the synthesis of adenosylmethionineanalogs of biotechnological interest

机译:热稳定的古细菌S-腺苷甲硫氨酸合成酶:一种有希望的工具,以提高生物技术兴趣的腺苷甲硫氨酸类似物的合成

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摘要

The naturally and widely occurring sulfonium compound, S-adenosyl-methionine (AdoMet), one of nature's most versatile molecules, is biosynthe-sized from methionine and ATP by AdoMet synthetase or methionine adeno-syltransferase (MAT) in a 2-step reaction in which the energy-rich sulfonium compound is formed by dephosphorylation of ATP. All living cells, with the only exception of some parasites and infectious agents, express MAT.
机译:天然和广泛存在的sulf化合物S-腺苷甲硫氨酸(AdoMet)是自然界中用途最广泛的分子之一,可通过AdoMet合成酶或甲硫氨酸腺苷基转移酶(MAT)在2步反应中由甲硫氨酸和ATP进行生物合成通过ATP的去磷酸化形成高能sulf化合物。除某些寄生虫和传染原外,所有活细胞均表达MAT。

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