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首页> 外文期刊>Biochemical Genetics >Role of genetic recombination in the molecular architecture of Papaya ringspot virus.
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Role of genetic recombination in the molecular architecture of Papaya ringspot virus.

机译：基因重组在木瓜环斑病毒分子结构中的作用。

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摘要

Papaya ringspot virus (PRSV) has a single-stranded RNA genome and causes severe economic losses both in cucurbits and papaya worldwide. The extent to which the genome of PRSV is shaped by recombination provides an understanding of the molecular evolution of PRSV and helps in studying features such as host specificity, geographic distribution, and its emergence as new epidemics. The PRSV-P-Indian isolate was completely sequenced and compared with 14 other isolates reported from the rest of the world for their phylogenetic survey of recombination events. Cistron-by-cistron sequence comparison and phylogenetic analysis based on full-genome polyprotein showed two distinct groupings of Asian and American isolates, although PRSV-P and W-India clustered along with the American isolates. Recombination sites were found throughout the genomes, except in the small 6K1 protein gene. A significant proportion of recombination hotspots was found in the P1 gene, followed by P3, cylindrical inclusion (CI), and helper component proteinase (HcPro). Correlations between the presence of recombination sites, geographic distribution, and phylogenetic relationship provide an opportunity to establish the molecular evolution and geographic route of PRSV.
机译：木瓜环斑病毒（PRSV）具有单链RNA基因组，在全世界的葫芦丝和木瓜中均造成严重的经济损失。 PRSV基因组通过重组形成的程度提供了对PRSV分子进化的理解，并有助于研究诸如宿主特异性，地理分布及其作为新流行病的出现等特征。对PRSV-P-Indian分离株进行了完整的测序，并将其与世界其他地区报道的其他14种分离株进行了重组事件的系统发育调查。基于顺反子的顺反子序列比较和基于全基因组多蛋白的系统发育分析显示，亚洲和美国分离株分为两个不同的组，尽管PRSV-P和W-India与美国分离株聚集在一起。除了小的6K1蛋白基因外，整个基因组中都存在重组位点。在P1基因中发现了很大比例的重组热点，其次是P3，圆柱形包涵体（CI）和辅助成分蛋白酶（HcPro）。重组位点的存在，地理分布和系统发育关系之间的相关性为建立PRSV的分子进化和地理途径提供了机会。

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