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首页> 外文期刊>Biochemical Genetics >Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia.
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Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia.

机译：俄罗斯Ta人中白细胞介素6，白细胞介素12和白细胞介素10基因多态性与原发性高血压的关系。

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Essential hypertension is a common disease with fatal clinical complications. Epidemiological and family studies have confirmed the role of genetic predisposition in its development. Hypertensive patients have been shown to have an altered profile of pro- and anti-inflammatory cytokines. The aim of our investigation was to reveal the association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension and its clinical complications in a Tatar ethnic group from Bashkortostan, Russia. The study involved 362 hypertensive patients and 244 healthy subjects from this Tatar ethnic group (Bashkortostan, Russia). DNA was isolated from whole venous blood using phenol-chloroform extraction by the standard method. IL6 -572 G/C, IL12B 1159 C/A, and IL10 -627 C/A genotypes were typed using polymerase chain reaction followed by restriction enzyme digestion. We found that the IL10 -627 *C/*C genotype was associated with decreased risk of hypertension (OR = 0.64, P = 0.035). IL6 genotypes and allele distribution did not differ significantly between subjects with and without hypertension, but the IL6 -572 *G/*G genotype frequency was found to be significantly higher among those patients who had stroke, compared with normotensive control subjects (P = 0.036). Carriers of the IL12B 1159 *A/*A genotype had a lower risk of stroke (OR = 0.38, P = 0.028). Our study has shown the association between IL10 -627 C/A polymorphism and essential hypertension in the Tatar ethnic group from Bashkortostan, Russia. The IL10 -627*C/*C genotype was found to be protective against hypertension. We also demonstrated that hypertensive patients with the IL12B *A/*A and IL6 *G/*G genotypes had increased risk of stroke. Our results suggest a role for cytokines in cardiovascular disease development in the Tatar ethnic group, but further investigation is needed.
机译：原发性高血压是一种具有致命临床并发症的常见疾病。流行病学和家庭研究已证实遗传易感性在其发展中的作用。高血压患者的促炎和抗炎细胞因子谱已改变。我们的研究目的是揭示俄罗斯巴什科尔托斯坦共和国塔塔尔族人群白细胞介素6，白细胞介素12和白细胞介素10基因多态性与原发性高血压及其临床并发症的关系。该研究涉及来自该塔塔尔族（俄罗斯巴什科尔托斯坦共和国）的362位高血压患者和244位健康受试者。通过标准方法使用苯酚-氯仿提取从全静脉血中分离DNA。使用聚合酶链式反应，然后进行限制性内切酶消化，对IL6-572 G / C，IL12B 1159 C / A和IL10-627 C / A基因型进行分型。我们发现IL10 -627 * C / * C基因型与高血压风险降低相关（OR = 0.64，P = 0.035）。 IL6基因型和等位基因分布在有高血压和无高血压的受试者之间没有显着差异，但是发现中风的患者中的IL6 -572 * G / * G基因型频率显着高于血压正常对照组（P = 0.036） ）。 IL12B 1159 * A / * A基因型携带者的中风风险较低（OR = 0.38，P = 0.028）。我们的研究表明，IL10 -627 C / A多态性与俄罗斯巴什科尔托斯坦共和国塔塔尔族原发性高血压之间的相关性。发现IL10 -627 * C / * C基因型可预防高血压。我们还证明，具有IL12B * A / * A和IL6 * G / * G基因型的高血压患者中风风险增加。我们的研究结果表明，在塔塔尔族人群中，细胞因子在心血管疾病的发展中具有重要作用，但还需要进一步研究。

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