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首页> 外文期刊>Biochemistry and molecular biology education >The Experimental Teaching Reform in Biochemistry and Molecular Biology for Undergraduate Students in Peking University Health Science Center
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The Experimental Teaching Reform in Biochemistry and Molecular Biology for Undergraduate Students in Peking University Health Science Center

机译：北京大学健康科学中心本科生生物化学与分子生物学实验教学改革

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Since 2010, second-year undergraduate students of an eight-year training program leading to a Doctor of Medicine degree or Doctor of Philosophy degree in Peking University Health Science Center (PKUHSC) have been required to enter the "Innovative talent training project." During that time, the students joined a research lab and participated in some original research work. There is a critical educational need to prepare these students for the increasing accessibility of research experience. The redesigned experimental curriculum of biochemistry and molecular biology was developed to fulfill such a requirement, which keeps two original biochemistry experiments (Gel filtration and Enzyme kinetics) and adds a new two-experiment component called "Analysis of antitumor drug induced apoptosis." The additional component, also known as the "project-oriented experiment" or the "comprehensive experiment," consists of Western blotting and a DNA laddering assay to assess the effects of etoposide (VP16) on the apoptosis signaling pathways. This reformed laboratory teaching system aims to enhance the participating students overall understanding of important biological research techniques and the instrumentation involved, and to foster a better understanding of the research process all within a classroom setting. Student feedback indicated that the updated curriculum helped them improve their operational and self-learning capability, and helped to increase their understanding of theoretical knowledge and actual research processes, which laid the groundwork for their future research work. (C) 2015 by The International Union of Biochemistry and Molecular Biology, 43: 428-433, 2015.
机译：自2010年起，要求参加北京大学健康科学中心（PKUHSC）获得医学博士学位或哲学博士学位的为期八年的培训课程的二年级本科生进入“创新型人才培养计划”。在此期间，学生们加入了研究实验室，并参与了一些原始的研究工作。迫切需要教育，以使这些学生为研究经验的日益普及做好准备。为了满足这一要求，开发了重新设计的生物化学和分子生物学实验课程，该课程保留了两个原始的生物化学实验（凝胶过滤和酶动力学），并增加了一个新的两项实验组成部分，即“抗肿瘤药物诱导的细胞凋亡分析”。额外的成分，也称为“面向项目的实验”或“综合实验”，由蛋白质印迹和DNA阶梯分析组成，以评估依托泊苷（VP16）对凋亡信号通路的影响。这种经过改革的实验室教学系统旨在增强与会学生对重要生物学研究技术和所涉及仪器的整体理解，并在课堂环境中促进对研究过程的更好理解。学生的反馈表明，更新的课程有助于他们提高操作和自学能力，并有助于加深他们对理论知识和实际研究过程的理解，这为他们未来的研究工作奠定了基础。 （C）2015年，国际生物化学与分子生物学联合会，43：428-433，2015。

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