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Analysis of TNF Polymorphisms in Turkish Systemic Sclerosis Patients with Interstitial Lung Involvement

机译:土耳其系统性硬化症伴间质性肺受累患者的TNF多态性分析

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摘要

Systemic sclerosis (SSc), also termed scleroderma, is a progressive, systemic disease of unknown origin characterized by excessive fibrosis, vascular abnormalities, and immune dysfunction (LeRoy et al. 1988). Clinical findings of scleroderma are sclerotic changes in the skin, joints, and internal organ systems, for instance, lungs, heart, and gastrointestinal tract (Haustein 2002; Medsger 1997). The major pathological process of scleroderma comprises inflammation (Brinckmann et al. 2005).
机译:系统性硬化症(SSc),也称为硬皮病,是一种进展性的,未知来源的系统性疾病,其特征是过度的纤维化,血管异常和免疫功能异常(LeRoy等,1988)。硬皮病的临床发现是皮肤,关节和内部器官系统(例如,肺,心脏和胃肠道)的硬化变化(Haustein 2002; Medsger 1997)。硬皮病的主要病理过程包括炎症(Brinckmann等,2005)。

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