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首页> 外文期刊>Biochemical Genetics >Regression of Walker 256 Carcinosarcoma in Vasopressin-Deficient Brattleboro Rats Is Accompanied by a Changed Laminin Pattern
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Regression of Walker 256 Carcinosarcoma in Vasopressin-Deficient Brattleboro Rats Is Accompanied by a Changed Laminin Pattern

机译：血管加压素缺乏的布拉特尔博罗大鼠中沃克256癌的消退伴随着层粘连蛋白模式的改变

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摘要

Walker 256 carcinosarcoma is a transplantable model of rat carcinoma that originally appeared spontaneously in mammary glands. The growth rate of Walker 256 carcinosarcoma in vasopressin-deficient Brattleboro rats is lower than in WAG rats and their congenic hybrids with normal vasopressin levels. Study of tumor proteins detected essential alterations. Tumor regression starting at the 14th day in Brattleboro rats was accompanied by changes in the laminin pattern. At the 21st day, the concentration of alpha-chains became twice as low, while beta-chains of laminin showed a sixfold increase compared to the initial equimolar correlation of bands. Congenic hybrids having one active copy of the vasopressin gene to provide a physiological level of hormone against the genetic background of Brattleboro rats show the same laminin alterations as WAG rats. They demonstrated a similar moderate increase of gamma-chains and threefold growth of alpha- and beta-chains of laminin in tumor tissue. It is supposed that vasopressin may be involved in the regulation of relevant local stimuli to trigger renovation of the laminin composition in a course of growing Walker 256 carcinosarcoma.
机译：Walker 256癌肉瘤是可移植的大鼠癌模型，最初自发出现在乳腺中。缺乏加压素的Brattleboro大鼠中Walker 256癌肉瘤的生长速度低于WAG大鼠及其具有正常加压素水平的同基因杂种的生长速度。对肿瘤蛋白的研究发现了必要的改变。 Brattleboro大鼠从第14天开始出现肿瘤消退，并伴随着层粘连蛋白模式的变化。在第21天，α链的浓度降低了两倍，而层粘连蛋白的β链的浓度则比条带的初始等摩尔相关性增加了六倍。具有一个维索加压素基因的有效拷贝以提供与Brattleboro大鼠遗传背景相对应的激素生理水平的激素的同质杂种，显示出与WAG大鼠相同的层粘连蛋白改变。他们证明了肿瘤组织中层粘连蛋白的γ链的中度增加类似，而层粘连蛋白的α和β链则增加了三倍。据推测，在沃克256型癌肉瘤的生长过程中，加压素可能参与了相关的局部刺激的调节，从而触发层粘连蛋白成分的更新。

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