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首页> 外文期刊>Biochemical Genetics >Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-kappa B, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions
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Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-kappa B, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions

机译：评价1,3-双（4-苯基）-1H-1,2,3-三唑基-2-丙醇对活检组织培养细胞中JAK2-STAT3，NF-κB和SOCS3基因表达水平的影响乳腺病变

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Breast cancer is the most frequent neoplasia in women and is responsible for approximately 13.8% of deaths per year for this gender. It has been suggested that JAK2, STAT3, and NF-kappa B gene expression is involved in this type of cancer. The objective of the present study was to determine the effect of bistriazole in these signaling pathways in patients with breast cancer and benign mammary lesions. The inhibitory concentration 50 of bistriazole was calculated in cell cultures of patients with benign lesions, Probit = 4.6 mu M with IC = 95%. The study was performed by examining 63 women who submitted to mammary biopsies. Biopsies of the mammary lesions were performed, gene expression was determined, and cells were cultured in the presence of 4.6 mu M bistriazole. We found that breast cancer is related to age greater than 50 (P <= 0.01), being overweight (P <= 0.023) and having a waist circumference larger than 80 cm (P <= 0.01). The gene expression of JAK2, STAT3, and NF-kappa B was higher in groups of patients with breast cancer, while SOCS3 expression was lower. After being exposed to bistriazole, the expression of JAK2 and STAT3 decreased, and the expression of SOCS3 and NF-kappa B increased. In conclusion, this molecule in development has an effect on the gene expression of JAK3 and STAT3; nevertheless, the lack of change in NF-kappa B indicates that it is not a regulator of inflammation, and therefore, more studies should be performed.
机译：乳腺癌是女性中最常见的赘生物，每年为此性别造成的死亡约占13.8％。已经提出JAK2，STAT3和NF-κB基因表达与这种类型的癌症有关。本研究的目的是确定双三唑在乳腺癌和乳腺良性病变患者中的这些信号通路中的作用。在患有良性病变的患者的细胞培养物中计算出双三唑的抑制浓度50，Probit = 4.6μM，IC = 95％。这项研究是通过检查63名接受乳房活检的妇女进行的。进行乳腺病变的活检，确定基因表达，并在4.6μM的双三唑存在下培养细胞。我们发现乳腺癌与年龄大于50岁（P <= 0.01），超重（P <= 0.023）和腰围大于80 cm（P <= 0.01）有关。在乳腺癌患者组中，JAK2，STAT3和NF-κB的基因表达较高，而SOCS3的表达较低。暴露于双三唑后，JAK2和STAT3的表达下降，SOCS3和NF-κB的表达上升。总之，该分子的发育对JAK3和STAT3的基因表达有影响。然而，NF-κB缺乏变化表明它不是炎症的调节剂，因此，应进行更多的研究。

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