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首页> 外文期刊>Biochemical Genetics >Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain
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Association of Genetic Polymorphism in the Interleukin-8 Gene with Risk of Oral Cancer and Its Correlation with Pain

机译：白细胞介素8基因多态性与口腔癌风险的关系及其与疼痛的关系

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摘要

Oral cancer is a multifactorial disease process and involves complex interactions between gene to gene and gene to environmental factors. Interleukin 8 (IL-8), a pro-inflammatory cytokine, having angiogenic activity with elevated expression in tumor cells, is reported to play an essential role in oral cancer development. This study was conducted with the aim to investigate the role of IL-8 (-A251T) gene polymorphism in susceptibility, progression, and self-reporting pain in oral cancer. The single nucleotide polymorphisms of the IL-8 (-A251T) gene were screened in 300 patients with oral cancer and 300 healthy controls, by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele frequencies were evaluated by chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. The results of the study demonstrated that IL-8 (-A251T) gene polymorphism was significantly associated with susceptibility of oral cancer, whereas its correlation with clinico-pathological status or pain due to oral cancer could not be established. The AT heterozygous (OR 5.31; CI 3.38-8.34; p 0.0001) and AA homozygous (OR 2.89; CI 1.76-4.75; p 0.0001) had a greater risk for oral cancer compared to TT homozygous. Furthermore, significantly increased values of A allele frequencies compared to T allele were observed in all patients (OR 1.56; CI 1.24-1.96; p 0.0002). Tobacco chewing and smoking were also found to influence the development of oral cancer and increased the incidence of pain in oral cancer patients. The findings of this study suggest that the IL-8 (-A251T) gene polymorphism may be associated with increased risk of oral cancer.
机译：口腔癌是一个多因素疾病过程，涉及基因与基因之间以及基因与环境因素之间的复杂相互作用。据报道，白细胞介素8（IL-8）是一种促炎性细胞因子，在肿瘤细胞中具有血管生成活性并具有高表达，在口腔癌的发展中起着至关重要的作用。进行这项研究的目的是研究IL-8（-A251T）基因多态性在口腔癌的易感性，进展和自我报告性疼痛中的作用。通过聚合酶链反应-限制性片段长度多态性筛选300例口腔癌患者和300例健康对照者的IL-8（-A251T）基因单核苷酸多态性。通过卡方检验评估基因型和等位基因频率，并使用具有95％置信区间（CI）的比值比（OR）来评估关联强度。研究结果表明，IL-8（-A251T）基因多态性与口腔癌的易感性显着相关，而无法确定其与临床病理状态或口腔癌引起的疼痛的相关性。与TT纯合子相比，AT杂合子（OR 5.31; CI 3.38-8.34; p 0.0001）和AA纯合子（OR 2.89; CI 1.76-4.75; p 0.0001）患口腔癌的风险更高。此外，在所有患者中观察到与T等位基因相比，A等位基因频率值显着增加（OR 1.56; CI 1.24-1.96; p 0.0002）。还发现咀嚼和吸烟会影响口腔癌的发展并增加口腔癌患者的疼痛发生率。这项研究的发现表明，IL-8（-A251T）基因多态性可能与口腔癌的风险增加有关。

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