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首页> 外文期刊>Bulletin du Cancer: Journal de l'Association Francaise pour l'Etude du Cancer >The intraoperative study of the sentinel lymph node was made possible through molecular analysis: A new concept and new applications for colon cancer? [L'étude peropératoire du ganglion sentinelle est devenue possible grace à l'analyse moléculaire: Nouveau concept et nouvelles applications pour les cancers coliques?]
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The intraoperative study of the sentinel lymph node was made possible through molecular analysis: A new concept and new applications for colon cancer? [L'étude peropératoire du ganglion sentinelle est devenue possible grace à l'analyse moléculaire: Nouveau concept et nouvelles applications pour les cancers coliques?]

机译：前哨淋巴结的术中研究通过分子分析得以实现：结肠癌的新概念和新应用？ [由于分子分析，术中前哨淋巴结研究已成为可能：结肠癌的新概念和新应用？]

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摘要

Sentinel lymph node (SLN) is a concept but also a technical possibility that can be studied and applied to almost all organs with cancer. For colorectal cancer surgery, some possibilities of using the SLN are possible, other implausible and some completely new especially aware of possible analysis of SLN by a molecular biology technique. The orientation of dissection or "lymph road mapping" can be designed for this case or the surgeon may want to limit his actions, particularly in patients with a history of colonic surgical resection, to keep the digestive function in maintaining vascular axes considered not involved in the metastatic process. The use of the single analysis of SLN to determine the positive or negative status of the cleaning has failed because of the frequency of false negatives in part to the size of colic advanced cancers at diagnosis. The use of "ultra-stading" by multiple section or exhaustion of the block, can lead to reconsider a stage N0 to N1 as a point, if the analysis technique remains in HES. Unlike the "ultra-stading" by RT- PCR or immunohistochemistry was even more discussed and seems not equivalent in terms of prognosis and therefore no giving formally justification for adjuvant therapy. Currently, a new technique for molecular biology, named "OSNA", allows an analysis of all the SLN in less than 45 minutes. It is therefore possible to obtain during surgery analysis of a node with the same level of information than traditional analysis using HES. If this node is positive and if the strategy in case of positive lymph nodes was determined prior for this patient, it is possible to anticipate this strategy and place after colectomy during the same anesthesia, venous access quickly to start postoperative chemotherapy. This new technique for analyzing lymph applied to the SLN opens a new potential application of this concept in digestive oncology.
机译：前哨淋巴结（SLN）是一个概念，也是一种技术可能性，可以研究并将其应用于几乎所有患有癌症的器官。对于结直肠癌手术，使用SLN的某些可能性是可能的，而另一些则是不可行的，有些是全新的，尤其是通过分子生物学技术对SLN的可能分析。可以针对这种情况设计解剖或“淋巴道定位”的方向，或者外科医生可能希望限制其行动，尤其是在有结肠手术切除史的患者中，以保持消化功能以维持被认为不参与的血管轴转移过程。使用SLN的单一分析来确定清洁的阳性或阴性状态失败了，因为假阴性的频率部分取决于诊断时绞痛晚期癌症的大小。如果分析技术保留在HES中，则多段使用“超稳定”或块耗尽将导致重新考虑阶段N0到N1。与通过RT-PCR或免疫组织化学进行的“超负荷试验”不同，它的预后似乎不尽相同，因此没有为佐剂治疗提供正式理由。当前，一种名为“ OSNA”的分子生物学新技术可以在不到45分钟的时间内对所有SLN进行分析。因此，有可能在手术过程中获得与使用HES的传统分析相同级别的信息。如果该淋巴结阳性，并且该患者事先确定了淋巴结阳性的策略，则可以在同一麻醉下预期该策略并在结肠切除术后放置，迅速进入静脉以开始术后化疗。这项用于SLN的淋巴分析新技术为消化肿瘤学打开了这一概念的潜在新应用。

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