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Antibiotic production in a spatially structured environment

机译：空间结构化环境中的抗生素生产

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摘要

Ecological factors influencing the effects of antibiotic production were explored experimentally and theoretically. A spatially structured model was used to model the dynamics of antibiotic-producing and nonproducing bacteria in which growth of the nonproducers was reduced by neighbouring antibiotic producers. Various factors affecting spatial interactions between the bacteria were examined for their impact on antibiotic producers. Spatial clustering had a positive impact on the effect of antibiotic production, as measured by the decline in growth of the nonproducing strain, while increasing the initial density of the nonproducing strain had a negative impact. Experiments examined the growth of antibiotic-producing Streptomyces species and a nonproducing, antibiotic-sensitive strain of Bacillus subtilis that were coinoculated on surface media. There was an effect of the Streptomyces on Bacillus growth in some experiments but not in others. In light of the predictions from the model, unintentional clustering of cells is a more likely explanation for this finding than different initial Bacillus densities. The importance of spatial structure seen in this study is consistent with a terrestrial rather than an aquatic distribution of antibiotic-producing bacteria, and may have implications in the search for novel antibiotics.
机译：实验和理论上探索了影响抗生素生产的生态因素。使用空间结构模型来模拟抗生素生产和非生产细菌的动力学，其中非生产者的生长被邻近的抗生素生产者减少。检查了影响细菌之间空间相互作用的各种因素对抗生素生产者的影响。用非生产菌株的生长下降来衡量，空间聚集对抗生素生产的影响具有积极影响，而增加非生产菌株的初始密度则具有负面影响。实验检查了产生抗生素的链霉菌种的生长以及在地面培养基上共接种的不产生抗生素的枯草芽孢杆菌敏感菌株。在某些实验中，链霉菌对芽孢杆菌的生长有影响，而在另一些实验中则没有。根据模型的预测，与不同的初始芽孢杆菌密度相比，细胞的非故意聚集是这一发现的更可能的解释。在这项研究中看到的空间结构的重要性与产生抗生素的细菌的陆地分布而不是水生分布一致，并且可能对寻找新型抗生素有影响。

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