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首页> 外文期刊>Biochemical Genetics >CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population.
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CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population.

机译：CTLA4 A49G多态性与中国人群的神经胶质瘤风险显着相关。

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摘要

Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case-control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA: P = 0.045; GG + AG vs. AA: P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.
机译：细胞毒性T淋巴细胞相关抗原4（CTLA4）A49G是一种多态性，已在各种癌症中进行了广泛研究。为了调查它是否与中国脑胶质瘤的发生有关，我们对670名患者和680名对照进行了一项病例对照研究。在该组中，我们发现该基因座的基因型与神经胶质瘤风险显着相关（GG vs. AA：P = 0.045; GG + AG vs. AA：P = 0.013）。在某些亚组中，G等位基因携带者的代表性明显降低。我们还观察到WHO组织学分期患者的多态性基因型与神经胶质瘤风险之间存在显着相关性。我们得出的结论是，CTLA4 A49G可能是潜在的临床生物标志物，可用于区分发生神经胶质瘤的高风险人群。

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