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首页> 外文期刊>Biochemical Genetics >Kell blood group system polymorphism in an urban Tunisian population.
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Kell blood group system polymorphism in an urban Tunisian population.

机译:突尼斯城市人口的凯尔血型系统多态性。

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摘要

Blood group systems such as Kell are significant in clinical and basic sciences (Daniels 2005). Their importance has been widely linked to their immunogenicity in some contexts, such as transfusion, feto-maternal tolerance, and transplantation (Lee et al. 1993; Murphy and Fraser 1997; Mannessier 2003; Faas et al. 2000; Kavita and Francine 2001; Dhodapkar and Blei 2001; Daniels et al. 2003; Gariod et al. 2004; Zimring et al. 2007). Such immunogenicity was linked to individual antigens that result from genetic polymorphisms. In this regard, the Kell blood group was described as the third most polymorphic system, with a group of 31 antigens (Kormoczi et al. 2009). Incompatibility for these antigens was defined as a critical factor involved in hemolytic transfusion reactions, autoimmune hemolytic anemia, and hemolytic disease of the newborn (Kanhai et al. 1987; Lee et al. 1993).
机译:血型系统(例如Kell)在临床和基础科学中具有重要意义(Daniels 2005)。在某些情况下,它们的重要性已与它们的免疫原性广泛相关,例如输血,胎儿母体耐受性和移植(Lee等,1993; Murphy和Fraser,1997; Mannessier,2003; Faas等,2000; Kavita和Francine,2001; Australia。 Dhodapkar和Blei 2001; Daniels等2003; Gariod等2004; Zimring等2007)。这种免疫原性与遗传多态性产生的单个抗原有关。在这方面,Kell血型被描述为第三多态系统,具有31种抗原(Kormoczi等,2009)。这些抗原的不相容性被定义为参与溶血性输血反应,自身免疫性溶血性贫血和新生儿溶血性疾病的关键因素(Kanhai等,1987; Lee等,1993)。

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