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首页> 外文期刊>Biochemical Genetics >Abnormal segregation of alleles and haplotypes at the polymorphic site of the PRNP gene within promoter and intron 1 regions in Polish Holstein-Friesian cattle
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Abnormal segregation of alleles and haplotypes at the polymorphic site of the PRNP gene within promoter and intron 1 regions in Polish Holstein-Friesian cattle

机译：在波兰荷斯坦-弗里斯牛的启动子和内含子1区域内PRNP基因多态位点的等位基因和单倍型异常分离

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摘要

Allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP gene was analyzed in Polish Holstein-Friesian cattle. More 23del/del homozygotes and fewer 23ins/ins homozygotes than expected were observed in the offspring of ♂ 23ins/del 9 ♀ 23ins/del parents. In the offspring of ♂ 23ins/del 9 ♀ 23del/del parents and ♂ 23del/ del 9 ♀ 23ins/del parents, a trend toward more 23del/del animals and fewer 23ins/ del animals than expected was noted. At the 12indel polymorphic site, the only trend found was one toward fewer 12ins/ins genotypes and more 12ins/del and 12del/del genotypes than expected in the offspring of ♂ 12ins/del 9 ♀ 12ins/del parents. An analysis of haplotype segregation revealed more 23del-12del/23del- 12del diplotypes and fewer 23ins-12ins/23ins-12ins diplotypes at the significance threshold than expected in the offspring of ♂ 23ins-12ins/23del-12del 9 ♀ 23ins- 12ins/23del-12del parents.
机译：在波兰荷斯坦-弗里斯兰牛中分析了PRNP基因启动子（23indel）和内含子1（12indel）区域内多态位点的等位基因和单倍型分离。在♂23ins / del 9♀23ins / del父母的后代中观察到的23del / del纯合子和23ins / ins纯合子比预期的要少。在♂23ins / del 9♀23del / del父母和♂23del / del 9♀23ins / del父母的后代中，发现了比预期更多的23del / del动物和更少的23ins / del动物的趋势。在12indel多态性位点，发现的唯一趋势是与12ins / del 9♀12ins / del父母的后代相比，预期的12ins / ins基因型更少，而12ins / del和12del / del基因型更多。对单倍型分离的分析显示，在显着性阈值下，23del-12del / 23del-12del双倍型和更少的23ins-12ins / 23ins-12ins双倍型比23ins-12ins / 23del-12del的后代9个23ins-12ins / 23del-12del的后代少。 -12del父母。

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