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首页> 外文期刊>Insect Biochemistry and Molecular Biology >Myofilament proteins in the synchronous flight muscles of Manduca sexta show both similarities and differences to Drosophila melanogaster
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Myofilament proteins in the synchronous flight muscles of Manduca sexta show both similarities and differences to Drosophila melanogaster

机译：曼杜卡（Manduca sexta）同步飞行肌肉中的肌丝蛋白与黑果蝇（Drosophila melanogaster）既有相似之处也有差异。

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摘要

Insect flight muscles have been classified as either synchronous or asynchronous based on the coupling between excitation and contraction. In the moth Manduca sexta, the flight muscles are synchronous and do not display stretch activation, which is a property of asynchronous muscles. We annotated the M. sexta genes encoding the major myofibrillar proteins and analyzed their isoform pattern and expression. Comparison with the homologous genes in Drosophila melanogaster indicates both difference and similarities. For proteins such as myosin heavy chain, tropomyosin, and troponin I the availability and number of potential variants generated by alternative spicing is mostly conserved between the two insects. The exon usage associated with flight muscles indicates that some exon sets are similarly used in the two insects, whereas others diverge. For actin the number of individual genes is different and there is no evidence for a flight muscle specific isoform. In contrast for troponin C, the number of genes is similar, as well as the isoform composition in flight muscles despite the different calcium regulation. Both troponin I and tropomyosin can include COOH-terminal hydrophobic extensions similar to tropomyosinH and troponinH found in D. melanogaster and the honeybee respectively. (C) 2015 Elsevier Ltd. All rights reserved.
机译：根据激发和收缩之间的耦合，昆虫的飞行肌肉被分为同步的或异步的。在天蛾蛾中，飞行肌肉是同步的并且不显示拉伸激活，这是异步肌肉的特性。我们注释了M. sexta基因，编码主要的肌原纤维蛋白，并分析了它们的同工型和表达。与果蝇中同源基因的比较表明差异和相似性。对于诸如肌球蛋白重链，原肌球蛋白和肌钙蛋白I之类的蛋白质，在两种昆虫之间，大多数情况下，通过交替加料生成的潜在变异体的可用性和数量都得到了保留。与飞行肌肉相关的外显子用法表明，在两种昆虫中类似地使用了一些外显子，而其他昆虫则发散。对于肌动蛋白，单个基因的数量是不同的，并且没有飞行肌特异性同工型的证据。与之相反，尽管钙调节不同，但肌钙蛋白C的基因数量以及飞行肌肉中的同工型组成相似。肌钙蛋白I和原肌球蛋白均可以包括COOH-末端疏水性延伸，分别类似于黑腹果蝇和蜜蜂中的原肌球蛋白H和肌钙蛋白H。 （C）2015 Elsevier Ltd.保留所有权利。

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