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A Birth-to-Death View of mRNA from the RNA Recognition Motif Perspective

机译：从RNA识别母题角度看从出生到死亡的mRNA

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摘要

RNA binding proteins are a large and varied group of factors that are the driving force behind post-tran-scriptional gene regulation. By analogy with transcription factors, RNA binding proteins bind to various regions of the mRNAs that they regulate, usually upstream or downstream from the coding region, and modulate one of the five major processes in mRNA metabolism: splicing, polyadenylation, export, translation and decay. The most abundant RNA binding protein domain is called the RNA Recognition Motif (RRM). It is probably safe to say that an RRM-containing protein is making some contact with an mRNA throughout its existence. The transcriptional counterpart would likely be the histones, yet the multitude of specific functions that are results of RRM based interactions belies the universality of the motif. This complex and diverse application of a single protein motif was used as the basis to develop an advanced graduate level seminar course in RNA:protein interactions. The course, utilizing a learner-centered empowerment model, was developed to dissect each step in RNA metabolism from the perspective of an RRM containing protein. This provided a framework to discuss the development of specificity for the RRM for each required process.
机译：RNA结合蛋白是多种多样的因素，是转录后基因调控的驱动力。与转录因子类似，RNA结合蛋白通常与编码区的上游或下游结合，调节其mRNA的各个区域，并调节mRNA代谢的五个主要过程之一：剪接，聚腺苷酸化，输出，翻译和衰变。最丰富的RNA结合蛋白结构域称为RNA识别基序（RRM）。可以肯定地说，含有RRM的蛋白质在其存在期间一直与mRNA接触。转录对应物很可能是组蛋白，但是基于RRM的相互作用产生的许多特定功能掩盖了基序的普遍性。单个蛋白质基序的这种复杂多样的应用被用作开发RNA：蛋白质相互作用的高级研究生课程的基础。本课程利用以学习者为中心的授权模型，从包含蛋白质的RRM角度剖析RNA代谢的每个步骤。这提供了一个框架来讨论针对每个所需过程的RRM的特异性开发。

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