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首页> 外文期刊>Insect Molecular Biology >Defending the fort: a role for defensin-2 in limiting Rickettsia
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Defending the fort: a role for defensin-2 in limiting Rickettsia

机译：保卫堡垒：防御素2在限制立克次体中的作用

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摘要

The importance of tick defensins is evidenced by their expression in a wide variety of tick tissues and prevalence across many tick genera. To date, the functional and biological significance of defensin-2 as a rickettsiastatic or rickettsiacidal antimicrobial peptide has not been addressed. In a previous study, defensin-2 transcription was shown to increase in Dermacentor variabilis ticks challenged with Rickettsia montanensis. In the present study, the hypothesis that defensin-2 is functional as a rickettsiastatic and/or rickettsiacidal antimicrobial peptide is tested. We show that defensin-2 plays a role in reducing burden after acquisition of Rickettsia montanensis through capillary feeding. Moreover, defensin-2 is shown to associate with R. montanensis in vitro and in vivo, causing cytoplasmic leakiness
机译：壁虱防御素在多种壁虱组织中的表达和在许多壁虱属中的普遍性证明了其重要性。迄今为止，防御素-2作为立克次酸抑制或立克次酸酸性抗菌肽的功能和生物学意义尚未得到解决。在先前的研究中，防御素2的转录显示在受褐变立克次体攻击的Dermacentor variabilis s中增加。在本研究中，检验了防御素2可以作为一种抗立克次酸和/或立克次酸酸性抗菌肽起作用的假设。我们显示防御素2在通过毛细补饲获得立克次体立克次体后在减轻负担中发挥作用。此外，防御素2已显示在体​​外和体内与褐红罗非鱼相关，导致细胞质渗漏

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