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首页> 外文期刊>Insect Molecular Biology >Gene structure and expression of nanos (nos) and oskar (osk) orthologues of the vector mosquito, Culex quinquefasciatus
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Gene structure and expression of nanos (nos) and oskar (osk) orthologues of the vector mosquito, Culex quinquefasciatus

机译:蚊子库蚊(Culex quinquefasciatus)的nanos和oskar(osk)直向同源物的基因结构和表达

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摘要

The products of the maternal-effect genes, nanos (nos) and oskar (osk), are important for the development of germ cells in insects. Furthermore, these genes have been proposed as candidates for donating functional DNA regulatory sequences for use in gene drive systems to control transmission of mosquito-borne pathogens. The nos and osk genes of the cosmopolitan vector mosquito, Culex quinquefasciatus, encode proteins with domains common to orthologues found in other mosquitoes. Expression analyses support the conclusion that the role of these genes is conserved generally among members of the nematocera. Hybridization in situ analyses reveal differences in mRNA distribution in early embryos in comparison with the cyclorraphan, Drosophila melanogaster, highlighting a possible feature in the divergence of the clades each insect represents.
机译:母本效应基因nanos(nos)和oskar(osk)的产物对于昆虫生殖细胞的发育很重要。此外,已经提出这些基因作为捐赠功能性DNA调节序列的候选物,以用于基因驱动系统以控制蚊子传播的病原体的传播。大都会媒介蚊子库克斯库克斯(Culex quinquefasciatus)的nos和osk基因编码的蛋白质具有其他蚊子中直向同源物共有的结构域。表达分析支持以下结论:这些基因的作用在线虫成员中通常是保守的。原位杂交分析显示,与环生raprraphan,果蝇Drosophila melanogaster相比,早期胚胎的mRNA分布有所不同,这突显了每种昆虫所代表的进化枝可能存在差异。

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