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首页> 外文期刊>International journal of dermatology >New insights into the pathophysiology and treatment of chronic itch in patients with end-stage renal disease, chronic liver disease, and lymphoma
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New insights into the pathophysiology and treatment of chronic itch in patients with end-stage renal disease, chronic liver disease, and lymphoma

机译：终末期肾脏疾病，慢性肝病和淋巴瘤患者慢性瘙痒的病理生理学和治疗方法的新见解

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摘要

Chronic itch associated with systemic diseases continues to be one of the most bothersome dermatological symptoms accompanying end-stage renal disease (ESRD), chronic liver diseases, and lymphoma. The International Forum for the Study of Itch has recently issued a consensus paper on different types of chronic pruritus, including pruritus in systemic diseases that can present with or without secondary skin changes. Various types of itch have been described based on the origin of the itch, which could be skin-related, neuropathic, systemic, or psycho-genie. At any given time patients with these systemic diseases may have more than one origin, for example, patients with ESRD could have neuropathic itch because of nerve fibers damage, as well as itch associated with skin inflammation such as perforating folliculitis. Itch adversely affects quality of life of patients, leading to sleep deprivation and depression that further augment itch. Chronic itch associated with systemic diseases range from mild to intractable, which is defined as a chronic itch state in which the cause cannot be removed or treated, and no relief or cure has been found in the generally accepted course of medical practice. In the last decade, there are significant advances in our understanding of specific itch neuronal pathways, mediators and relevant receptors, opening the field for development of new anti-pruritic strategies. The purpose of this review is to highlight the new findings related to the pathophysiological mechanisms and the treatment of itch associated with the most common systemic diseases including ESRD, chronic liver disease, and lymphoma.
机译：与全身性疾病相关的慢性瘙痒仍然是伴随终末期肾脏疾病（ESRD），慢性肝病和淋巴瘤的最令人讨厌的皮肤病症状之一。国际瘙痒研究论坛最近发表了一份关于不同类型的慢性瘙痒症的共识文件，其中包括全身性皮肤瘙痒症，无论是否伴有继发性皮肤改变，均会出现。已经基于瘙痒的起源描述了各种类型的瘙痒，其可能是皮肤相关的，神经性的，全身性的或精神病的。在任何给定的时间，患有这些系统性疾病的患者可能有多个起源，例如，患有ESRD的患者可能会因神经纤维受损而出现神经性瘙痒，以及与皮肤炎症（如穿孔性毛囊炎）相关的瘙痒。瘙痒会对患者的生活质量产生不利影响，导致睡眠不足和抑郁，进一步加剧瘙痒。与全身性疾病相关的慢性瘙痒从轻度到顽固不等，这被定义为一种慢性瘙痒状态，其中无法消除或治疗病因，并且在普遍接受的医学实践中未发现任何缓解或治愈的方法。在过去的十年中，我们对特定瘙痒神经元途径，介体和相关受体的理解有了重大进展，为开发新的止痒策略开辟了领域。这篇综述的目的是强调与病理生理机制和与最常见的全身性疾病（包括ESRD，慢性肝病和淋巴瘤）相关的瘙痒治疗相关的新发现。

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