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首页> 外文期刊>International journal of dermatology >Overall survival in erythrodermic cutaneous T-cell lymphoma: an analysis of prognostic factors in a cohort of patients with erythrodermic cutaneous T-cell lymphoma.
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Overall survival in erythrodermic cutaneous T-cell lymphoma: an analysis of prognostic factors in a cohort of patients with erythrodermic cutaneous T-cell lymphoma.

机译：红皮病性皮肤T细胞淋巴瘤的总体生存：分析红皮病性皮肤T细胞淋巴瘤患者的预后因素。

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BACKGROUND: The most common cutaneous T-cell lymphomas (CTCLs) are mycosis fungoides and Sezary syndrome. AIM: To determine whether blood stage and other prognostic variables affect overall survival (OS) in CTCL. METHODS: We studied retrospectively 1197 CTCL patients seen at the M.D. Anderson Cancer Center since 1987. RESULTS: We identified 124 (10.3%) patients with erythrodermic CTCL (E-CTCL), 63% of whom had positive gene rearrangements in skin and 19 of whom had no evidence of hematologic involvement. The median age at diagnosis was 63 years (range, 26-90 years); the male to female ratio was 1.3 : 1. OS curves were estimated by the Kaplan-Meier method and compared using log-rank tests. The median OS in all 124 E-CTCL patients was 5.1 years (range, 0.4-18.6 years) regardless of the cause of death or blood involvement. Patients were stratified by the H0-H4 staging system with manual or flow cytometric determination of Sezary cell counts (Russell-Jones R, Whittaker SJ. Sezary syndrome: diagnostic criteria and therapeutic options. Semin Cutan Med Surg 2000; 19: 100-108). The median OS was 7.6 years for H0-H2 (< 1000 Sezary cells/L) (n = 23), 5.4 years for H3 (>or= 1000 to or= 10,000 Sezary cells/L) (n = 22) (P = 0.011). Treatment with systemic steroids, age, serum lactate dehydrogenase, and white blood cell count >or= 20,000 microL were significant prognostic factors, but large cell transformation, T-cell receptor gene rearrangement, tumor-node-metastasis stage, treatments, and CD4 : CD8 ratio were not. In multivariate analysis, advanced age and elevated lactate dehydrogenase were the strongest predictors of a poor prognosis. CONCLUSIONS: Serum LDH and age were the strongest predictive factors for OS in E-CTCL.
机译：背景：最常见的皮肤T细胞淋巴瘤（CTCL）是蕈样真菌病和Sezary综合征。目的：确定血液阶段和其他预后变量是否影响CTCL的总体生存（OS）。方法：我们回顾性研究了自1987年以来在MD Anderson癌症中心就诊的1197例CTCL患者。结果：我们确定了124例（10.3％）患有红皮病CTCL（E-CTCL）的患者，其中63％的皮肤基因重排阳性，其中19例的皮肤他们没有血液学证据。诊断时的中位年龄为63岁（范围26-90岁）。男女之比为1.3：1。通过Kaplan-Meier方法估算OS曲线，并使用对数秩检验进行比较。所有124名E-CTCL患者的中位OS均为5.1年（范围0.4-18.6岁），无论死亡原因或血液受累情况如何。通过H0-H4分期系统对患者进行分层，其中手动或流式细胞术确定Sezary细胞计数（Russell-Jones R，Whittaker SJ。Sezary综合征：诊断标准和治疗选择。SeminCutan Med Surg 2000; 19：100-108） 。 H0-H2的中位OS为7.6年（<1000 Sezary细胞/ L）（n = 23），H3的中位OS为5.4年（> or = 1000到<或= 10,000 Sezary cells / L）（n = 79），和H4（>或= 10,000 Sezary细胞/ L）为2.4年（n = 22）（P = 0.011）。全身性类固醇，年龄，血清乳酸脱氢酶和白细胞计数>或等于20,000 microL的治疗是重要的预后因素，但大细胞转化，T细胞受体基因重排，肿瘤淋巴结转移阶段，治疗和CD4： CD8的比例没有。在多变量分析中，高龄和乳酸脱氢酶升高是预后不良的最强预测指标。结论：血清LDH和年龄是E-CTCL中OS的最强预测因素。

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