CHARACTERIZATION OF TARGET ANTIGENS FROM ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES IN AUTOIMMUNE HEPATITIS TYPE-I

Kellner R.; Mayet WJ.; Orth T.

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CHARACTERIZATION OF TARGET ANTIGENS FROM ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES IN AUTOIMMUNE HEPATITIS TYPE-I

机译：自身免疫性I型肝炎的抗中性细胞血浆抗体靶向抗原的表征

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The occurrence of anti-neutrophil cytoplasmic antibodies (ANCA) has been described in sera of patients with autoimmune hepatitis (AIH). The significance of this finding remains uncertain and the nature of the target antigen(s) has not yet been defined. We studied 32 sera from patients with AIH type-I and prepared extracts of human neutrophils to identify the target antigen(s). A 43 kDa dominant immunoreactive protein was found and identified as the cytoskeletal component actin. Initial studies to define the antigenic determinants identified three different actin domains. [References: 18]

机译：已经在自身免疫性肝炎（AIH）患者的血清中描述了抗中性粒细胞胞浆抗体（ANCA）的出现。该发现的重要性仍不确定，并且靶抗原的性质尚未定义。我们研究了I型AIH患者的32份血清，并制备了人类嗜中性粒细胞的提取物以鉴定目标抗原。发现一种43 kDa的显性免疫反应蛋白，并被鉴定为细胞骨架成分肌动蛋白。定义抗原决定簇的初步研究鉴定了三个不同的肌动蛋白结构域。 [参考：18]

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《Electrophoresis: The Official Journal of the International Electrophoresis Society》 |1997年第4期|共4页
作者
Kellner R.; Mayet WJ.; Orth T.;
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正文语种 eng
中图分类化学;
关键词
Autoimmune hepatitis; Anti-neutrophil cytoplasmic antibodies; Protein sequence analysis; Target antigen; Epitope mapping; Liver-diseases; Prevalence; Proteins;

机译：自身免疫性肝炎;抗中性粒细胞胞浆抗体;蛋白质序列分析;靶抗原;表位作图;肝病;患病率;蛋白质;

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1. CHARACTERIZATION OF TARGET ANTIGENS FROM ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES IN AUTOIMMUNE HEPATITIS TYPE-I [J] . Kellner R., Mayet WJ., Orth T. Electrophoresis: The Official Journal of the International Electrophoresis Society . 1997,第3a4期

机译：自身免疫性I型肝炎的抗中性细胞血浆抗体靶向抗原的表征
2. Anti-endothelial cell antibodies in patients with AAV: The relationship with ANCA? Comment on: Identification of target antigens of anti-endothelial cell antibodies in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides: A proteomic approach [J] . Gou Shen-Ju, Fu Ping Clinical immunology: The official journal of the Clinical Immunology Society . 2014,第2期

机译：AAV患者的抗内皮细胞抗体：与ANCA的关系？评论：抗中性粒细胞胞浆抗体相关血管炎患者抗内皮细胞抗体靶抗原的鉴定：蛋白质组学方法
3. Reply to "Anti-endothelial cell antibodies in patients with MV: The relationship with ANCA? Comment on: Identification of target antigens of anti-endothelial cell antibodies in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides: A proteomic approach" by Shen-Ju Gou, Ping Fu [J] . Regent Alexis, Mouthon Luc Clinical immunology: The official journal of the Clinical Immunology Society . 2014,第2期

机译：回复“沉着患者中性粒细胞胞浆抗体相关血管炎患者抗内皮细胞抗体靶抗原的鉴定：蛋白质组学方法”的回复“ MV患者的抗内皮细胞抗体：与ANCA的关系？”评论：居苟，平富
4. Role of microsomal antigens in autoimmune hepatitis [C] . C. P. STRASSBUR Falk Symposium . 2005

机译：微粒体抗原在自身免疫性肝炎中的作用
5. Cell-surface display applications for characterization of antibody-epitope recognition patterns and antigen discovery in autoimmune disease. [D] . Ballew, John Thomas. 2013

机译：细胞表面显示应用在自身免疫性疾病中表征抗体-表位识别模式和发现抗原。
6. High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis [O] . J Sobajima, S Ozaki, H Uesugi, 1999

机译：高迁移率族（HMG）非组蛋白染色体蛋白HMG1和HMG2是自身免疫性肝炎中核周抗中性粒细胞胞浆抗体的重要靶抗原
7. High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis [O] . Sobajima, J, Ozaki, S, Uesugi, H, 1999

机译：高迁移率族（HMG）非组蛋白染色体蛋白HMG1和HMG2是自身免疫性肝炎中核周抗中性粒细胞胞浆抗体的重要靶抗原
8. Hepatitis B Virus Infection and Hepatocellular Carcinoma: Correlation between IgM Antibody to Hepatitis B Core Antigen, Hepatitis B e Antigen, and Hepatitis B DNA. [R] . Sjogren, M. H., Dusheiko, G. M., Kew, M. C., 1988

机译：乙型肝炎病毒感染和肝细胞癌：乙型肝炎核心抗原，乙型肝炎抗原和乙型肝炎DNa的Igm抗体之间的相关性。

CHARACTERIZATION OF TARGET ANTIGENS FROM ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES IN AUTOIMMUNE HEPATITIS TYPE-I

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