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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >LARGE-SCALE PROTEIN MODELLING AND INTEGRATION WITH THE SWISS-PROT AND SWISS-2DPAGE DATABASES - THE EXAMPLE OF ESCHERICHIA COLI
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LARGE-SCALE PROTEIN MODELLING AND INTEGRATION WITH THE SWISS-PROT AND SWISS-2DPAGE DATABASES - THE EXAMPLE OF ESCHERICHIA COLI

机译：大型蛋白质建模和与SWISS-PROT和SWISS-2DPAGE数据库的整合-以大肠杆菌为例

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Knowledge-based molecular modelling of proteins has proven useful in many instances, including the rational design of mutagenesis experiments, but it has generally been limited by the availability of expensive computer hardware and software. To overcome these limitations, we developed the SWISS-MODEL server for automated knowledge-based protein modelling. The SWISS-MODEL server uses the Brookhaven Protein Data Bank as a source of structural information and automatically generates protein models for sequences which share significant similarities with at least one protein of known three-dimensional structure. We have now used the software framework of the server to generate large collections of protein models, and established the SWISS-MODEL Repository. a new database for automatically generated and theoretical protein models. This repository is directly integrated with the SWISS-PROT and SWISS-2DPAGE databases through the ExPASy World Wide Web server (URL is http ://expasy.hcuge.ch), Here we present an illustration of this process by an application to the Escherichia coli sequences. [References: 18]
机译：事实证明，基于知识的蛋白质分子建模在许多情况下都是有用的，包括诱变实验的合理设计，但通常受到昂贵的计算机硬件和软件的可用性的限制。为了克服这些限制，我们开发了SWISS-MODEL服务器，用于基于知识的自动化蛋白质建模。 SWISS-MODEL服务器使用Brookhaven蛋白质数据库作为结构信息源，并自动为与至少一种具有已知三维结构的蛋白质具有显着相似性的序列生成蛋白质模型。现在，我们已经使用服务器的软件框架来生成蛋白质模型的大量集合，并建立了SWISS-MODEL存储库。用于自动生成和理论蛋白质模型的新数据库。该存储库通过ExPASy万维网服务器（URL为http://expasy.hcuge.ch）直接与SWISS-PROT和SWISS-2DPAGE数据库集成。在这里，我们通过Escherichia的应用程序来举例说明此过程。大肠杆菌序列。 [参考：18]

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