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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >On-line coupling of packed capillary electrochromatography with coordination ion spray-mass spectrometry for the separation of enantiomers
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On-line coupling of packed capillary electrochromatography with coordination ion spray-mass spectrometry for the separation of enantiomers

机译：填充毛细管电色谱与配位离子喷雾质谱联用在线分离对映体

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摘要

Pressure-supported packed capillary electrochromatography (CEC) and packed capillary high-performance liquid chromatography (pHPLC) have been coupled on-line to electrospray ionization-mass spectrometry (ESI-MS) and coordination ion spray-mass spectrometry (CIS-MS). Separation of enantiomers of barbiturates and chlorinated alkyl phenoxypropanoates were performed on a permethy ated beta-cycloclextrin stationary phase by pressure-supported CEC. For on-line detect on with ESI- and CIS-MS, a modified sheath-liquid interface was used. CIS-MS is a universal, novel ionization technique which improves the selectivity as well as the sensitivity. Charged complexes were formed through the addition of central complexing ions such as silver(l), cobalt(I 1), copper(II), and lithium(l) to the sheath flow. Advantages of CIS-MS detection compared to the ESI-MS mode are discussed. In the CIS-MS mode, increased sensitivity and high selectivity was attained through different possibilities of complexation. The superiority of pressure-supported CEC compared to pHPLC in the hyphenation with CIS-MS is demonstrated. [References: 32]
机译：压力支撑的填充毛细管电色谱（CEC）和填充毛细管高效液相色谱（pHPLC）已在线耦合到电喷雾电离质谱（ESI-MS）和配位离子喷雾质谱（CIS-MS）。巴比妥酸酯和氯代烷基苯氧基丙酸酯的对映异构体的分离是通过压力支持的CEC在甲基化的β-环糊精固定相上进行的。为了使用ESI-和CIS-MS在线检测，使用了改良的鞘液界面。 CIS-MS是一种通用的新型电离技术，可提高选择性和灵敏度。通过向鞘流中添加中心络合离子（如银（l），钴（I 1），铜（II）和锂（l））形成带电荷的络合物。讨论了与ESI-MS模式相比CIS-MS检测的优势。在CIS-MS模式下，通过不同的络合可能性获得了更高的灵敏度和更高的选择性。证明了在与CIS-MS联用时，压力支持的CEC与pHPLC相比具有优越性。 [参考：32]

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