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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >Separation of anti-tumor peptides by capillary electrophoresis in organic solvent containing background electrolytes
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Separation of anti-tumor peptides by capillary electrophoresis in organic solvent containing background electrolytes

机译：在包含背景电解质的有机溶剂中通过毛细管电泳分离抗肿瘤肽

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摘要

Connections between the calculated and measured electrophoretic mobilities (mu(ep)) determined by capillary electrophoresis as well as connections between the measured and calculated diffusion coefficients of anti-tumor peptides have been investigated in background electrolytes (BGEs) containing different organic solvents (acetonitrile, methanol, ethanol and isopropanol). Comparison of the electrophoretic mobility (mu(ep)) values revealed discrepancies between the measured and calculated values. However, no change in the migration order or selectivity could be expected from the calculated mu(ep) values, variation of both properties was observed applying organic solvents as BGE modifiers. Experimental determination of the diffusion coefficient suggested that the effect of the organic solvents is not restricted to the change of the BGE viscosity. The reason for the discrepancy between the measured and calculated mobility values might be the possible conformation and/or solvation changes of the peptide caused by the different organic solvents. [References: 27]
机译：在含不同有机溶剂（乙腈，乙腈，甲醇，乙醇和异丙醇）。电泳迁移率（mu（ep））值的比较显示了测量值和计算值之间的差异。但是，从计算的mu（ep）值可以看出迁移顺序或选择性不会发生变化，使用有机溶剂作为BGE改性剂时，观察到两种性质均发生变化。扩散系数的实验确定表明，有机溶剂的作用不限于BGE粘度的变化。测量的迁移率值与计算的迁移率值之间存在差异的原因可能是由不同的有机溶剂引起的肽可能的构象和/或溶剂化变化。 [参考：27]

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