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首页> 外文期刊>Electrophoresis: The Official Journal of the International Electrophoresis Society >ACID-CATALYZED REDUCTIVE AMINATION OF ALDOSES WITH 8-AMINOPYRENE-1,3,6-TRISULFONATE
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ACID-CATALYZED REDUCTIVE AMINATION OF ALDOSES WITH 8-AMINOPYRENE-1,3,6-TRISULFONATE

机译：用8-氨基戊烯-1,3,6-三磺酸酯进行醛类的酸催化还原胺化

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摘要

The reductive amination of monosaccharides with 8-aminopyrene-1,3,6-trisulfonate (APTS) in seven different organic acids including the commonly used acetic acid was investigated by capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection. The correlation between the yields of the saccharide-APTS adducts and pK(a) of the organic acid catalyst is consistent with general acid catalysis of the rate-determining step of the reductive amination reaction. Derivatization in the presence of organic acids of higher strength than acetic acid produced substantially higher yields of APTS-sugar adducts, an effect which is more pronounced for N-acetylamino sugars. Optimum yields were obtained using citric acid as a catalyst. Conversion of a few nanomoles of neutral saccharides to the APTS derivatives is achieved at 75 degrees C in less than 60 min. [References: 19]
机译：通过毛细管电泳（CE）和激光诱导荧光（LIF）检测，研究了在8种不同的有机酸（包括常用的乙酸）中用8-氨基py-1,3,6-三磺酸盐（APTS）对单糖的还原胺化作用。糖类-APTS加合物的收率与有机酸催化剂的pK（a）之间的相关性与还原胺化反应速率确定步骤的一般酸催化相一致。在强度比乙酸高的有机酸存在下进行衍生化可显着提高APTS糖加合物的收率，这种作用对于N-乙酰氨基糖更为明显。使用柠檬酸作为催化剂可获得最佳产率。在不到60分钟的时间内，在75摄氏度下将几纳摩尔的中性糖类转化为APTS衍生物。 [参考：19]

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