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首页> 外文期刊>Electromyography and Clinical Neurophysiology: International Bimonthly Review >Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research.
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Effect of age on pupillary light reflex: evaluation of pupil mobility for clinical practice and research.

机译：年龄对瞳孔光反射的影响：用于临床实践和研究的瞳孔活动度评估。

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PURPOSE: The aim of this study was to provide a data base for the measurement of various parameters of the pupil light reflex in normal subjects using a fast video pupillometry device (262 frames/sec). METHOD: One hundred healthy subjects took part in the study aged 44.31+/-18.11 years. Subjects were divided in two (2) groups according to age: 18-50 years of age (group 1) and 51-81 years of age (group 2). All subjects were examined between 09.00 and 15.00 and the re-test examination was repeated exactly 24 hours later. All variables showed satisfactory test-retest reliability (Pearson test-retest showed values over 0. 70 for all parameters besides Time for Maximum Constriction (T3. 0.62) and Recovery (R%: 0.57)). RESULTS: The Latency of pupil reaction to light (Ti) was not affected by Age. Baseline Pupil Radius (RI) after 2 min of dark adaptation was statistically smaller in the elderly group p < 0.001; Maximum Constriction Velocity (VCmax), Maximum Constriction Acceleration (ACmax) and Amplitude (AMP)were significantly smaller in the elderly group (p < 0.001) when compared to group 1. When all parameters were studied their correlation showed a statistical significant difference for R1, R2, VCmax, ACmax and AMP when related to Age. However when Age was taken into account through the use of partial correlation, the relation between R1, R2 and AMP remained unaltered, but the relations between R1 and VCmax and ACmax were dramatically reduced from -0.39 to -0.21 and from -0.45 to -0.09 respectively indicating that the relation observed between Ri and VCmax and ACmax was due mainly to the Age of the subjects. CONCLUSION: The results suggest that age influences Baseline Pupil Size, Maximum Constriction Velocity (VCmax) and Acceleration (ACmax), while the Latency of the light reflex remains unaltered.
机译：目的：本研究的目的是提供一个数据库，用于使用快速视频瞳孔测定仪（262帧/秒）测量正常受试者的瞳孔光反射的各种参数。方法：一百名健康受试者参加了这项研究，年龄为44.31 +/- 18.11岁。根据年龄将受试者分为两（2）组：18-50岁（组1）和51-81岁（组2）。在09.00至15.00之间对所有受试者进行检查，并在24小时后恰好重复进行重新测试。所有变量均显示令人满意的重测可靠性（Pearson重测显示除最大收缩时间（T3。0.62）和恢复率（R％：0.57）以外，所有参数的值均超过0. 70。结果：瞳孔对光（Ti）的反应潜伏期不受年龄的影响。统计学上，老年人组在黑暗适应2分钟后的瞳孔半径（RI）较小，p <0.001;与组1相比，老年组的最大收缩速度（VCmax），最大收缩加速度（ACmax）和振幅（AMP）明显较小（p <0.001）。研究所有参数后，它们的相关性显示R1的统计差异显着，R2，VCmax，ACmax和AMP（与年龄相关）。但是，通过使用偏相关将年龄考虑在内时，R1，R2和AMP之间的关系保持不变，但R1与VCmax和ACmax之间的关系从-0.39显着减小到-0.21，从-0.45减小到-0.09分别表明，Ri与VCmax和ACmax之间的关系主要归因于受试者的年龄。结论：结果表明年龄影响基线瞳孔大小，最大收缩速度（VCmax）和加速度（ACmax），而光反射的潜伏期保持不变。

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