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首页> 外文期刊>International Journal of Medicinal Mushrooms >The Medicinal Benefits of Lentinan (beta-1, 3-D glucan) from Lentinus edodes (Berk.) Singer (Shiitake Mushroom) Through Oral Administration
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The Medicinal Benefits of Lentinan (beta-1, 3-D glucan) from Lentinus edodes (Berk.) Singer (Shiitake Mushroom) Through Oral Administration

机译：香菇（Berk。）歌手（香菇）的香菇多糖（口服香菇）的伦蒂南（β-1，3-D葡聚糖）的药用价值

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摘要

Lentinan is a purified beta-giucan isolated from Lentinm edodes (shiitake mushroom). Past studies have shown that lentinan possesses strong inhibitory effects on tumors induced in mice via intravenous and intraperitoneal injection. The anti tumor andimmunomodulation effects of lentinan through oral administration were investigated in our study, and the results obtained proved its efficacy. The results showed that prefeeding of the mice for 7 days at an optimum dose of 3 mg/mouse was most effective against tumor induction, achieving a tumor inhibition rate (TIR) of 94.44%. Four key cytokines involved in the inhibition of tumor development—namely, interleukin-lalpha, interleukin-2, interferon-gamma, and tumor necrosis factor-alpha—were induced significantly in the blood of the lentinan-fed mice. This also indicated the immunomodulating effect of lentinan. Further investigation showed that lentinan is capable of activating the lymphocytes of the host. Three types of immunodeficient mice—namely, nude mice (athymic mice), B-cell-deficient mice, and SCID (severe combined immunodeficient) mice—were used to demonstrate the protective capability of the activated lymphocytes. Normal AKR mice fed with lentinan for 7 days were sacrificed, and lymphocyteswere isolated from their spleens. Adoptive transfer of these lymphocytes was done by inoculation via the immunodeficient mice tails. The sizes of the developed tumors (induced using the human colon carcinoma cells) were scored after 1 month. Large tumors were observed to be present in those immunodeficient mice that received lymphocytes from buffer solution-fed mice, whereas very small tumors or no tumors were observed in mice that received lymphocytes from lentinan-fed mice. The passively transferredlentinan-primed lymphocytes were able to restrict tumor development in these immunodeficient mice.
机译：Lentinan是从Lentinm香菇（香菇）中分离得到的纯化的β-菊苣。过去的研究表明，香菇多糖通过静脉内和腹膜内注射对小鼠诱发的肿瘤具有强烈的抑制作用。本研究探讨了香菇多糖口服给药的抗肿瘤和免疫调节作用，所得结果证明了其有效性。结果表明，以3 mg /小鼠的最佳剂量预饲7天对小鼠的肿瘤诱导最有效，达到94.44％的肿瘤抑制率。在由伦地南喂养的小鼠的血液中显着诱导了四种与抑制肿瘤发生有关的关键细胞因子，即白介素-1α，白介素-2，干扰素-γ和肿瘤坏死因子-α。这也表明了香菇多糖的免疫调节作用。进一步的研究表明，香菇多糖能够激活宿主的淋巴细胞。三种类型的免疫缺陷小鼠，即裸鼠（运动性小鼠），B细胞缺陷小鼠和SCID（严重联合免疫缺陷）小鼠，被用来证明活化淋巴细胞的保护能力。处死喂以香豆素7天的正常AKR小鼠，并从其脾脏中分离淋巴细胞。通过免疫缺陷小鼠尾巴接种来完成这些淋巴细胞的过继转移。 1个月后对发展中的肿瘤的大小（使用人结肠癌细胞诱导的）进行评分。在那些从缓冲溶液喂养的小鼠那里接受淋巴细胞的免疫缺陷小鼠中观察到大肿瘤，而在从伦地南喂养的小鼠那里接受淋巴细胞的小鼠中观察到很小的肿瘤或没有肿瘤。被动转移的香豆素引发的淋巴细胞能够限制这些免疫缺陷小鼠的肿瘤发展。

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