Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

Wang W.; Chen Z.; Mao Z.; Zhang H.; Ding X.; Chen S.; Zhang X.; Xu R.; Zhu B.

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Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

机译：核仁蛋白Spindlin1识别H3K4甲基化并刺激rRNA基因的表达

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The tandem Tudor-like domain-containing protein Spindlin1 has been reported to be a meiotic spindle-associated protein. Here we report that Spindlin1 is not associated with the spindle in mouse embryonic fibroblast cells during mitotic divisions. In interphase cells, Spindlin1 specifically localizes to the nucleoli. Moreover, Spindlin1 is a histone methylation effector protein that specifically recognizes H3K4 methylation. Finally, Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of rRNA genes.

机译：据报道，串联的含Tudor样结构域的蛋白Spindlin1是减数分裂纺锤体相关蛋白。在这里我们报告Spindlin1与有丝分裂分裂期间小鼠胚胎成纤维细胞中的纺锤体不相关。在相间细胞中，Spindlin1特异性定位于核仁。此外，Spindlin1是一种组蛋白甲基化效应蛋白，可特异性识别H3K4甲基化。最后，Spindlin1定位于活性核糖体DNA（rDNA）重复序列，而Spindlin1促进了rRNA基因的表达。

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《EMBO reports》 |2011年第11期|共7页
作者
Wang W.; Chen Z.; Mao Z.; Zhang H.; Ding X.; Chen S.; Zhang X.; Xu R.; Zhu B.;
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正文语种 eng
中图分类分子生物学;
关键词
histone methylation; nucleolus; rRNA; Spindlin1; transcription;

机译：组蛋白甲基化;核仁;rRNA;Spindlin1;转录;

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专利

1. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes [J] . Wang W., Chen Z., Mao Z., EMBO reports . 2011,第11期

机译：核仁蛋白Spindlin1识别H3K4甲基化并刺激rRNA基因的表达
2. A Concerted DNA Methylation/Histone Methylation Switch Regulates rRNA Gene Dosage Control and Nucleolar Dominance [J] . Richard J. Lawrence, Keith Earley, Olga Pontes, Molecular cell . 2004,第4期

机译：协调一致的DNA甲基化/组蛋白甲基化开关调节rRNA基因剂量控制和核仁优势。
3. Expression of DNMT3A transcripts and nucleolar localization of DNMT3A protein in human testicular and fibroblast cells suggest a role for de novo DNA methylation in nucleolar inactivation. [J] . Galetzka D, Tralau T, Stein R, Journal of cellular biochemistry. . 2006,第4期

机译：DNMT3A转录本的表达和DNMT3A蛋白在人睾丸和成纤维细胞中的核仁定位表明，从头DNA甲基化在核仁失活中发挥了作用。
4. The Effect of Mono- and Di-Methylation of H3K4 on Transcription Might Be Associated with Gene Length [C] . Deng Yangyang, Dai Xianhua 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：H3K4的单甲基化和二甲基化对转录的影响可能与基因长度有关
5. Pax7BP, a novel Pax7-binding protein, bridges Pax7 and the H3K4 histone methyltransferase complex and mediates the expression of Pax7 target genes in myoblasts. [D] . Diao, Yarui. 2011

机译：Pax7BP是一种新颖的Pax7结合蛋白，可桥接Pax7和H3K4组蛋白甲基转移酶复合物，并介导成肌细胞中Pax7靶基因的表达。
6. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes [O] . Weixiang Wang, Zhi Chen, Zhuo Mao, 2011

机译：核仁蛋白Spindlin1识别H3K4甲基化并刺激rRNA基因的表达
7. A Concerted DNA Methylation/Histone Methylation Switch Regulates rRNA Gene Dosage Control and Nucleolar Dominance [O] . Richard J. Lawrence, Keith Earley, Olga Pontes, 2013

机译：协调一致的DNA甲基化/组蛋白甲基化开关调节rRNA基因剂量控制和核仁优势。

Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

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