Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis

Nishida Y.; Sugi T.; Nonomura M.; Mori I.

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Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis

机译：鉴定AFD神经元是秀丽隐杆线虫热引物中CREB蛋白的作用位点

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Behaviour is a consequence of computation in neural circuits composed of massive synaptic connections among sensory neurons and interneurons. The cyclic AMP response element-binding protein (CREB) responsible for learning and memory is expressed in almost all neurons. Nevertheless, we find that the Caenorhabditis elegans CREB orthologue, CRH-1, is only required in the single bilateral thermosensory neuron AFD, for a memory-related behaviour. Restoration of CRH-1 in AFD of CREB-depleted crh-1 mutants rescues its thermotactic defect, whereas restorations in other neurons do not. In calcium-imaging analyses, the AFD neurons of CREB-depleted crh-1 mutants exhibit an abnormal response to temperature increase. We present a new platform for analysing the mechanism of behavioural memory at single-cellular resolution within the neural circuit.

机译：行为是由感觉神经元和中间神经元之间的大量突触连接组成的神经回路中计算的结果。负责学习和记忆的环状AMP反应元件结合蛋白（CREB）在几乎所有神经元中都有表达。但是，我们发现秀丽隐杆线虫CREB直系同源物CRH-1仅在单个双侧热感觉神经元AFD中才需要进行与记忆有关的行为。 CREB耗尽的crh-1突变体AFD中CRH-1的恢复可以挽救其热策略缺陷，而其他神经元的恢复则不能。在钙成像分析中，CREB耗尽的crh-1突变体的AFD神经元对温度升高表现出异常反应。我们提出了一个新的平台，用于分析神经回路内单细胞分辨率下行为记忆的机制。

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《EMBO reports》 |2011年第8期|共8页
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Nishida Y.; Sugi T.; Nonomura M.; Mori I.;
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正文语种 eng
中图分类分子生物学;
关键词
behaviour; CREB; memory; thermotaxis;

机译：行为;CREB;记忆;热运动;

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专利

1. Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis [J] . Nishida Y., Sugi T., Nonomura M., EMBO reports . 2011,第8期

机译：鉴定AFD神经元是秀丽隐杆线虫热引物中CREB蛋白的作用位点
2. The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation [J] . Samuel H Chung, Damon A Clark, Christopher V Gabel, BMC Neuroscience . 2006,第1期

机译：飞秒激光消融分析AFD神经元在秀丽隐杆线虫中的作用
3. Age‐dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans [J] . Tzu‐Ting Huang, Hironori J. Matsuyama, Yuki Tsukada, Aging cell. . 2020,第5期

机译：Caenorhabditis elegans中热轰动神经元和热传感器神经元和热诱变行为的年龄依赖性变化
4. Genetic evidence in Caenorhabditis elegans implicates a syntaxin-lA-binding protein as critical for presynaptic volatile anesthetic action [C] . Laura B. Metz, Christine Liu, J. Stephen Hunt, International Conference on Basic and Systemic Mechanisms of Anesthesia . 2005

机译：Caenorhabditisegans的遗传证据意味着一种对突触前挥发性麻醉作用的棘突-Ata结合的蛋白质
5. A Computational Investigation of the Biophysical Mechanisms Underlying Thermotaxis in the AFD Neurons of Caenorhabditis elegans [D] . Mobille, Zachary. 2021

机译：秀丽隐杆线虫AFD神经元的热神经元潜在的生物物理机制的计算研究
6. Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis [O] . Yukuo Nishida, Takuma Sugi, Mayu Nonomura, 2011

机译：鉴定AFD神经元为秀丽隐杆线虫热引物中CREB蛋白的作用位点
7. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis [O] . Dong Wang, Damien O’Halloran, Miriam B. Goodman 2013

机译：GCY-8，PDE-2和NCS-1是CGMP依赖性热扫描级联的关键元素，其在AFD神经元中负责C. Elegans Thermotaxis

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Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis

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