• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endocrinology >T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice.
【24h】

T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice.

机译：在非肥胖糖尿病H2h4小鼠中，T辅助17型免疫应答对于碘诱导的自身免疫性甲状腺炎的发展起着不可或缺的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

T helper type 1(Th1)/Th2 paradigm has been expanded by discovery of a novel effector T cell (T(eff)) subset, Th17 cells, which produce a proinflammatory cytokine IL-17. Th17 cells have recently been shown to play a major role in numerous autoimmune diseases that had previously been thought to be Th1-dominant diseases. We here studied the significance of Th17 cells in iodine-induced autoimmune thyroiditis in nonobese diabetic-H2(h4) mice, a mouse model of Hashimoto's thyroiditis in humans, which spontaneously develop antithyroglobulin autoantibodies and intrathyroidal lymphocyte infiltration when supplied with iodine in the drinking water. We observed increased numbers of Th1 and Th17 cells in spleen and accumulation of both types of T(eff) in the thyroid glands of iodine-fed wild-type mice, indicating that Th17 cells as well as Th1 cells constitute thyroid lesions. Furthermore, the incidence and severity of intrathyroidal lymphocyte infiltration, and the titers of antithyroglobulin autoantibodies were markedly reduced in iodine-treated IL-17(-/-) mice as compared with wild-type mice. Of interest, IL-17(+/-) mice showed an intermediate phenotype. Therefore, the present study, together with a previous report demonstrating the importance of Th1, not Th2, immune response for developing thyroiditis using mice deficient for interferon-gamma or IL-4, clearly indicates that both Th1 and Th17 cells are critical T(eff) subsets for the pathogenesis of spontaneous autoimmune thyroiditis in nonobese diabetic-H2(h4) mice.
机译：T辅助类型1（Th1）/ Th2范式已通过发现新型效应T细胞（T（eff））亚群Th17细胞得以扩展，该子可产生促炎性细胞因子IL-17。 Th17细胞最近被证明在许多以前被认为是Th1主导疾病的自身免疫疾病中起主要作用。我们在这里研究了非肥胖型糖尿病H2（h4）小鼠中碘诱导的自身免疫性甲状腺炎中Th17细胞的重要性，这是人类桥本甲状腺炎的小鼠模型，在饮用水中补充碘后会自发产生抗甲状腺球蛋白自身抗体和甲状腺内淋巴细胞浸润。我们观察到碘喂养的野生型小鼠的脾脏中Th1和Th17细胞数量的增加以及两种类型的T（eff）的积累，表明Th17细胞以及Th1细胞构成了甲状腺病变。此外，与野生型小鼠相比，在用碘处理的IL-17（-/-）小鼠中，甲状腺内淋巴细胞浸润的发生率和严重性以及抗甲状腺球蛋白自身抗体的滴度显着降低。有趣的是，IL-17（+/-）小鼠表现出中间表型。因此，本研究与先前的报告一起证明了Th1而非Th2免疫应答对于使用γ-干扰素或IL-4缺陷的小鼠发展为甲状腺炎的重要性，清楚地表明Th1和Th17细胞都是关键的T（eff ）非肥胖糖尿病H2（h4）小鼠中自发性自身免疫性甲状腺炎发病机制的子集。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号